The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine
The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine
Osteoarthritis (OA) is the most common cause of arthritis worldwide and represents a significant healthcare burden, particularly in the context of an ageing population. Traditionally, painkillers, injections and physiotherapy have been the mainstay of treatment, with patients being referred for joint replacement surgery (arthroplasty) when these options fail. Whilst effective in reducing pain and improving joint function, these approaches are not without potential complications. With the development of tissue-engineering techniques over recent years there has been considerable interest in applying these strategies to provide new, innovative, alternative effective means of treating OA. This review explores the unique microenvironment present within an osteoarthritic joint, highlighting the features that comprise the osteoarthritic niche and could be modulated in the development of novel treatments for OA. Existing tissue-engineering strategies for repairing bone and cartilage defects are discussed, with particular reference to how these might be modified, both to improve existing treatments, such as impaction bone grafting, as well as in the development of future treatments for OA. Copyright © 2012 John Wiley & Sons, Ltd.
Williams, E.L.
814864e1-1145-45a9-a9e8-521821a969cb
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
9 April 2012
Williams, E.L.
814864e1-1145-45a9-a9e8-521821a969cb
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Williams, E.L., Edwards, C.J., Cooper, C. and Oreffo, R.O.C.
(2012)
The osteoarthritic niche and modulation of skeletal stem cell function for regenerative medicine.
Journal of Tissue Engineering and Regenerative Medicine.
(doi:10.1002/term.1455).
(PMID:22489025)
Abstract
Osteoarthritis (OA) is the most common cause of arthritis worldwide and represents a significant healthcare burden, particularly in the context of an ageing population. Traditionally, painkillers, injections and physiotherapy have been the mainstay of treatment, with patients being referred for joint replacement surgery (arthroplasty) when these options fail. Whilst effective in reducing pain and improving joint function, these approaches are not without potential complications. With the development of tissue-engineering techniques over recent years there has been considerable interest in applying these strategies to provide new, innovative, alternative effective means of treating OA. This review explores the unique microenvironment present within an osteoarthritic joint, highlighting the features that comprise the osteoarthritic niche and could be modulated in the development of novel treatments for OA. Existing tissue-engineering strategies for repairing bone and cartilage defects are discussed, with particular reference to how these might be modified, both to improve existing treatments, such as impaction bone grafting, as well as in the development of future treatments for OA. Copyright © 2012 John Wiley & Sons, Ltd.
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Published date: 9 April 2012
Organisations:
Human Development & Health
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Local EPrints ID: 345794
URI: http://eprints.soton.ac.uk/id/eprint/345794
ISSN: 1932-6254
PURE UUID: 20e62e16-1f93-41fd-8751-610787711d90
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Date deposited: 04 Dec 2012 11:29
Last modified: 18 Mar 2024 02:51
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E.L. Williams
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