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Cephalosporin-3'-diazeniumdiolates: targeted no-donor prodrugs for dispersing bacterial biofilms

Cephalosporin-3'-diazeniumdiolates: targeted no-donor prodrugs for dispersing bacterial biofilms
Cephalosporin-3'-diazeniumdiolates: targeted no-donor prodrugs for dispersing bacterial biofilms
Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3?-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial ?-lactamases and facilitates this two-step biofilm erradication.
antibiotics, biofilms, cephalosporins, nitric oxide, prodrugs
1433-7851
9057-9060
Barraud, N.
04b83401-f5b4-4e8b-8f7d-03f7b3a693f5
Kardak, B.G.
8cbdddd8-141b-4239-be5a-46bda5b17015
Yepuri, N.R.
710b8f2f-5557-4e93-a447-fa72bbc699f6
Howlin, R.
c2264245-b6cf-485d-b8bf-7a059e72bb79
Webb, Jeremy S.
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Kjelleberg, S.
04464230-455d-42c6-999c-72a12ad9d4d4
Rice, S.A.
7733572d-1916-4cad-b156-2ea9bd45d80d
Kelso, M.J.
a86ec82f-0b46-4875-a5ec-d87c6b6bf22f
Barraud, N.
04b83401-f5b4-4e8b-8f7d-03f7b3a693f5
Kardak, B.G.
8cbdddd8-141b-4239-be5a-46bda5b17015
Yepuri, N.R.
710b8f2f-5557-4e93-a447-fa72bbc699f6
Howlin, R.
c2264245-b6cf-485d-b8bf-7a059e72bb79
Webb, Jeremy S.
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Kjelleberg, S.
04464230-455d-42c6-999c-72a12ad9d4d4
Rice, S.A.
7733572d-1916-4cad-b156-2ea9bd45d80d
Kelso, M.J.
a86ec82f-0b46-4875-a5ec-d87c6b6bf22f

Barraud, N., Kardak, B.G., Yepuri, N.R., Howlin, R., Webb, Jeremy S., Faust, S.N., Kjelleberg, S., Rice, S.A. and Kelso, M.J. (2012) Cephalosporin-3'-diazeniumdiolates: targeted no-donor prodrugs for dispersing bacterial biofilms. Angewandte Chemie International Edition, 51 (36), 9057-9060. (doi:10.1002/anie.201202414).

Record type: Article

Abstract

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3?-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial ?-lactamases and facilitates this two-step biofilm erradication.

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More information

e-pub ahead of print date: 13 August 2012
Published date: 3 September 2012
Keywords: antibiotics, biofilms, cephalosporins, nitric oxide, prodrugs
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 345971
URI: http://eprints.soton.ac.uk/id/eprint/345971
DOI: doi:10.1002/anie.201202414
ISSN: 1433-7851
PURE UUID: 5b94bf6a-0748-4cfe-b619-8edbdf6cb8e7
ORCID for Jeremy S. Webb: ORCID iD orcid.org/0000-0003-2068-8589
ORCID for S.N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 10 Dec 2012 14:06
Last modified: 15 Mar 2024 03:26

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Contributors

Author: N. Barraud
Author: B.G. Kardak
Author: N.R. Yepuri
Author: R. Howlin
Author: Jeremy S. Webb ORCID iD
Author: S.N. Faust ORCID iD
Author: S. Kjelleberg
Author: S.A. Rice
Author: M.J. Kelso

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