Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors
Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors
A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.
61-64
Spencer, John
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Amin, Jahangir
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Boddiboyena, Ramesh
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Packham, Graham
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Cavell, Breeze E.
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Syed Alwi, Sharifah S.
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Paranal, Ronald M.
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Heightman, Tom D.
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Wang, Minghua
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Marsden, Brian
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Coxhead, Peter
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Guille, Matthew
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Tizzard, Graham J.
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Coles, Simon J.
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Bradner., James E.
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January 2012
Spencer, John
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Amin, Jahangir
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Boddiboyena, Ramesh
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Packham, Graham
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Cavell, Breeze E.
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Syed Alwi, Sharifah S.
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Paranal, Ronald M.
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Heightman, Tom D.
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Wang, Minghua
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Marsden, Brian
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Coxhead, Peter
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Guille, Matthew
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Tizzard, Graham J.
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Coles, Simon J.
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Bradner., James E.
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Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Syed Alwi, Sharifah S., Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner., James E.
(2012)
Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors.
MedChemComm, 3 (1), .
(doi:10.1039/c1md00203a).
Abstract
A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.
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More information
Published date: January 2012
Organisations:
Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences, Faculty of Medicine, Bioengineering Group
Identifiers
Local EPrints ID: 345986
URI: http://eprints.soton.ac.uk/id/eprint/345986
ISSN: 2040-2503
PURE UUID: dab5f2a0-bcad-460e-ab61-de4d1b26b296
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Date deposited: 10 Dec 2012 16:52
Last modified: 15 Mar 2024 03:10
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Contributors
Author:
John Spencer
Author:
Jahangir Amin
Author:
Ramesh Boddiboyena
Author:
Breeze E. Cavell
Author:
Sharifah S. Syed Alwi
Author:
Ronald M. Paranal
Author:
Tom D. Heightman
Author:
Minghua Wang
Author:
Brian Marsden
Author:
Peter Coxhead
Author:
Matthew Guille
Author:
James E. Bradner.
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