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Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors
Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors
A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.
2040-2503
61-64
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Boddiboyena, Ramesh
b8b1a75f-0db8-40a8-8c52-aeb7f24f8009
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Cavell, Breeze E.
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Syed Alwi, Sharifah S.
58980b19-b871-4df6-858b-7aa192f094e5
Paranal, Ronald M.
665c05d6-68e3-45b9-bb9b-e650c6ffddee
Heightman, Tom D.
c844f4ce-0a70-41c2-b098-6e40b942322a
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Marsden, Brian
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Coxhead, Peter
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Guille, Matthew
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Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Bradner., James E.
b585ceed-2a44-4891-b9c8-682275863ad0
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Amin, Jahangir
15a45a7a-1741-45fa-9f31-9aa6ef1924ed
Boddiboyena, Ramesh
b8b1a75f-0db8-40a8-8c52-aeb7f24f8009
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Cavell, Breeze E.
e85ef588-d947-44c3-904f-32f7b61bd610
Syed Alwi, Sharifah S.
58980b19-b871-4df6-858b-7aa192f094e5
Paranal, Ronald M.
665c05d6-68e3-45b9-bb9b-e650c6ffddee
Heightman, Tom D.
c844f4ce-0a70-41c2-b098-6e40b942322a
Wang, Minghua
68242ec4-8322-4bb5-8386-a9326f18d074
Marsden, Brian
b8ed05de-18e7-4657-814b-eb90774245e9
Coxhead, Peter
7d49795f-0a1b-416c-a61b-b367be46ae8d
Guille, Matthew
dfefb828-7c5b-4529-8df6-d7a10d8d5b67
Tizzard, Graham J.
8474c0fa-40df-43a6-a662-7f3c4722dbf2
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Bradner., James E.
b585ceed-2a44-4891-b9c8-682275863ad0

Spencer, John, Amin, Jahangir, Boddiboyena, Ramesh, Packham, Graham, Cavell, Breeze E., Syed Alwi, Sharifah S., Paranal, Ronald M., Heightman, Tom D., Wang, Minghua, Marsden, Brian, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J., Coles, Simon J. and Bradner., James E. (2012) Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors. MedChemComm, 3 (1), 61-64. (doi:10.1039/c1md00203a).

Record type: Article

Abstract

A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.

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More information

Published date: January 2012
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences, Faculty of Medicine, Bioengineering Group

Identifiers

Local EPrints ID: 345986
URI: https://eprints.soton.ac.uk/id/eprint/345986
ISSN: 2040-2503
PURE UUID: dab5f2a0-bcad-460e-ab61-de4d1b26b296
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691
ORCID for Graham J. Tizzard: ORCID iD orcid.org/0000-0002-1577-5779
ORCID for Simon J. Coles: ORCID iD orcid.org/0000-0001-8414-9272

Catalogue record

Date deposited: 10 Dec 2012 16:52
Last modified: 15 Aug 2019 00:50

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Contributors

Author: John Spencer
Author: Jahangir Amin
Author: Ramesh Boddiboyena
Author: Graham Packham ORCID iD
Author: Breeze E. Cavell
Author: Sharifah S. Syed Alwi
Author: Ronald M. Paranal
Author: Tom D. Heightman
Author: Minghua Wang
Author: Brian Marsden
Author: Peter Coxhead
Author: Matthew Guille
Author: Simon J. Coles ORCID iD
Author: James E. Bradner.

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