Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case
Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case
This study has provided detailed ex vivo analysis of retrieved human tissue engineered bone and possible reasons for the observed construct failure are discussed in this article. The impacted bone displayed some evidence of remodeled trabecular structure, although the bone marrow aspirate that was initially combined with the allograft contained a relatively low concentration of osteoprogenitor cells. Cellular augmentation was insufficient to overcome the osteoclastic process associated with renewed cyst formation. Concentration or culture expansion of osteoprogenitor cells from aspirated bone marrow is recommended for biological augmentation of bone graft.
461-467
Aarvold, Alexander
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Smith, James O.
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Tayton, Edward R
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Tilley, Simon
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Dawson, Jon I.
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Lanham, Stuart A.
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Briscoe, Adam
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Dunlop, Douglas G.
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Oreffo, Richard O.C.
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July 2011
Aarvold, Alexander
11dc317f-47fd-4b2c-b0a6-78688c679b5a
Smith, James O.
027f2a5a-1966-4077-97a7-f70d2e6b06b2
Tayton, Edward R
96db2df6-e8ca-4709-a13d-16b8f05aff5c
Tilley, Simon
cd468907-2c35-4f52-a817-6ad0c7977608
Dawson, Jon I.
b220fe76-498d-47be-9995-92da6c289cf3
Lanham, Stuart A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Briscoe, Adam
40a57aa0-be88-47a6-b528-ae8f0914d0e7
Dunlop, Douglas G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Aarvold, Alexander, Smith, James O., Tayton, Edward R, Tilley, Simon, Dawson, Jon I., Lanham, Stuart A., Briscoe, Adam, Dunlop, Douglas G. and Oreffo, Richard O.C.
(2011)
Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case.
Regenerative Medicine, 6 (4), .
(doi:10.2217/rme.11.33).
(PMID:21749204)
Abstract
This study has provided detailed ex vivo analysis of retrieved human tissue engineered bone and possible reasons for the observed construct failure are discussed in this article. The impacted bone displayed some evidence of remodeled trabecular structure, although the bone marrow aspirate that was initially combined with the allograft contained a relatively low concentration of osteoprogenitor cells. Cellular augmentation was insufficient to overcome the osteoclastic process associated with renewed cyst formation. Concentration or culture expansion of osteoprogenitor cells from aspirated bone marrow is recommended for biological augmentation of bone graft.
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Published date: July 2011
Organisations:
Human Development & Health
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Local EPrints ID: 345993
URI: http://eprints.soton.ac.uk/id/eprint/345993
ISSN: 1746-0751
PURE UUID: 142f4e04-c2fe-44e3-86c3-6174e3b042a1
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Date deposited: 11 Dec 2012 13:55
Last modified: 15 Mar 2024 03:31
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Author:
Alexander Aarvold
Author:
James O. Smith
Author:
Edward R Tayton
Author:
Simon Tilley
Author:
Stuart A. Lanham
Author:
Adam Briscoe
Author:
Douglas G. Dunlop
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