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Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case

Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case
Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case
This study has provided detailed ex vivo analysis of retrieved human tissue engineered bone and possible reasons for the observed construct failure are discussed in this article. The impacted bone displayed some evidence of remodeled trabecular structure, although the bone marrow aspirate that was initially combined with the allograft contained a relatively low concentration of osteoprogenitor cells. Cellular augmentation was insufficient to overcome the osteoclastic process associated with renewed cyst formation. Concentration or culture expansion of osteoprogenitor cells from aspirated bone marrow is recommended for biological augmentation of bone graft.
1746-0751
461-467
Aarvold, Alexander
11dc317f-47fd-4b2c-b0a6-78688c679b5a
Smith, James O.
027f2a5a-1966-4077-97a7-f70d2e6b06b2
Tayton, Edward R
96db2df6-e8ca-4709-a13d-16b8f05aff5c
Tilley, Simon
cd468907-2c35-4f52-a817-6ad0c7977608
Dawson, Jon I.
b220fe76-498d-47be-9995-92da6c289cf3
Lanham, Stuart A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Briscoe, Adam
40a57aa0-be88-47a6-b528-ae8f0914d0e7
Dunlop, Douglas G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Aarvold, Alexander
11dc317f-47fd-4b2c-b0a6-78688c679b5a
Smith, James O.
027f2a5a-1966-4077-97a7-f70d2e6b06b2
Tayton, Edward R
96db2df6-e8ca-4709-a13d-16b8f05aff5c
Tilley, Simon
cd468907-2c35-4f52-a817-6ad0c7977608
Dawson, Jon I.
b220fe76-498d-47be-9995-92da6c289cf3
Lanham, Stuart A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Briscoe, Adam
40a57aa0-be88-47a6-b528-ae8f0914d0e7
Dunlop, Douglas G.
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Aarvold, Alexander, Smith, James O., Tayton, Edward R, Tilley, Simon, Dawson, Jon I., Lanham, Stuart A., Briscoe, Adam, Dunlop, Douglas G. and Oreffo, Richard O.C. (2011) Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case. Regenerative Medicine, 6 (4), 461-467. (doi:10.2217/rme.11.33). (PMID:21749204)

Record type: Article

Abstract

This study has provided detailed ex vivo analysis of retrieved human tissue engineered bone and possible reasons for the observed construct failure are discussed in this article. The impacted bone displayed some evidence of remodeled trabecular structure, although the bone marrow aspirate that was initially combined with the allograft contained a relatively low concentration of osteoprogenitor cells. Cellular augmentation was insufficient to overcome the osteoclastic process associated with renewed cyst formation. Concentration or culture expansion of osteoprogenitor cells from aspirated bone marrow is recommended for biological augmentation of bone graft.

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More information

Published date: July 2011
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 345993
URI: https://eprints.soton.ac.uk/id/eprint/345993
ISSN: 1746-0751
PURE UUID: 142f4e04-c2fe-44e3-86c3-6174e3b042a1
ORCID for Stuart A. Lanham: ORCID iD orcid.org/0000-0002-4516-264X
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 11 Dec 2012 13:55
Last modified: 06 Jun 2018 13:02

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Contributors

Author: Alexander Aarvold
Author: James O. Smith
Author: Edward R Tayton
Author: Simon Tilley
Author: Jon I. Dawson
Author: Stuart A. Lanham ORCID iD
Author: Adam Briscoe
Author: Douglas G. Dunlop

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