Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries
Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries
A library of pyridines and pyrimidines has been synthesised in excellent yields employing microwave and flow chemistry methodologies. Work-up bottlenecks have been facilitated substantially by the use of supported reagents and many of the final compounds have been studied in the solid state by single crystal X-ray diffraction.
heterocycles, microwaves, parallel synthesis, piperazines, flow chemistry
5905-5909
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Patel, Hiren
73682df0-69ba-44c9-88b2-5c19f7f23677
Callear, Samantha K.
5af7f651-0ff0-4163-80b3-34996d62022a
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Deadman, John J.
6ec79e7a-322c-4d5c-99fd-25480e53ec05
9 November 2011
Spencer, John
a3cf55cd-a4c7-4af6-b16c-96c8fb8c4cf4
Patel, Hiren
73682df0-69ba-44c9-88b2-5c19f7f23677
Callear, Samantha K.
5af7f651-0ff0-4163-80b3-34996d62022a
Coles, Simon J.
3116f58b-c30c-48cf-bdd5-397d1c1fecf8
Deadman, John J.
6ec79e7a-322c-4d5c-99fd-25480e53ec05
Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J. and Deadman, John J.
(2011)
Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries.
Tetrahedron Letters, 52 (45), .
(doi:10.1016/j.tetlet.2011.07.147).
Abstract
A library of pyridines and pyrimidines has been synthesised in excellent yields employing microwave and flow chemistry methodologies. Work-up bottlenecks have been facilitated substantially by the use of supported reagents and many of the final compounds have been studied in the solid state by single crystal X-ray diffraction.
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Published date: 9 November 2011
Keywords:
heterocycles, microwaves, parallel synthesis, piperazines, flow chemistry
Organisations:
Organic Chemistry: Synthesis, Catalysis and Flow
Identifiers
Local EPrints ID: 346171
URI: http://eprints.soton.ac.uk/id/eprint/346171
ISSN: 0040-4039
PURE UUID: 8da4345f-1793-42aa-a744-54636834920b
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Date deposited: 18 Dec 2012 11:52
Last modified: 15 Mar 2024 03:01
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Contributors
Author:
John Spencer
Author:
Hiren Patel
Author:
Samantha K. Callear
Author:
John J. Deadman
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