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Epigenetic mechanisms and models in the origins of asthma

Epigenetic mechanisms and models in the origins of asthma
Epigenetic mechanisms and models in the origins of asthma
Purpose of review: epigenetic mechanisms have the ability to alter the phenotype without changing the genetic code. The science of epigenetics has grown considerably in recent years, and future epigenetically based treatments or prevention strategies are likely. Epigenetic associations with asthma have received growing interest because genetic and environmental factors have been unable to independently explain the cause of asthma.

Recent findings: recent findings suggest that both the environment and underlying genetic sequence variation influence DNA methylation, which in turn seems to modify the risk conferred by genetic variants for various asthma phenotypes. In particular, DNA methylation may act as an archive of a variety of early developmental exposures, which then can modify the risk related to genetic variants.

Summary: current asthma treatments may control the symptoms of asthma but do not modify its natural history. Epigenetic mechanisms and novel explanatory models provide burgeoning approaches to significantly increase our understanding of the initiation and progression of asthma. Due to the inheritance of epigenetics, we anticipate a rapid emergence of critical information that will provide novel treatment strategies for asthma in the current generation and ultimately the prevention of asthma in future generations
1528-4050
63-69
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Everson, Todd
8ffc34fe-a3b9-49b3-b3d3-7bd1d386a9cd
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Ziyab, Ali H.
12905e44-3fd1-47c2-98e5-35320e89815b
Everson, Todd
8ffc34fe-a3b9-49b3-b3d3-7bd1d386a9cd
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a

Karmaus, Wilfried, Ziyab, Ali H., Everson, Todd and Holloway, John W. (2013) Epigenetic mechanisms and models in the origins of asthma. Current Opinion in Allergy and Clinical Immunology, 13 (1), 63-69. (doi:10.1097/ACI.0b013e32835ad0e7). (PMID:23242116)

Record type: Article

Abstract

Purpose of review: epigenetic mechanisms have the ability to alter the phenotype without changing the genetic code. The science of epigenetics has grown considerably in recent years, and future epigenetically based treatments or prevention strategies are likely. Epigenetic associations with asthma have received growing interest because genetic and environmental factors have been unable to independently explain the cause of asthma.

Recent findings: recent findings suggest that both the environment and underlying genetic sequence variation influence DNA methylation, which in turn seems to modify the risk conferred by genetic variants for various asthma phenotypes. In particular, DNA methylation may act as an archive of a variety of early developmental exposures, which then can modify the risk related to genetic variants.

Summary: current asthma treatments may control the symptoms of asthma but do not modify its natural history. Epigenetic mechanisms and novel explanatory models provide burgeoning approaches to significantly increase our understanding of the initiation and progression of asthma. Due to the inheritance of epigenetics, we anticipate a rapid emergence of critical information that will provide novel treatment strategies for asthma in the current generation and ultimately the prevention of asthma in future generations

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More information

Published date: February 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 346375
URI: http://eprints.soton.ac.uk/id/eprint/346375
ISSN: 1528-4050
PURE UUID: 16eaf263-a34d-4775-ae48-e68289f9ec1d
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 02 Jan 2013 08:52
Last modified: 09 Jan 2022 02:54

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Contributors

Author: Wilfried Karmaus
Author: Ali H. Ziyab
Author: Todd Everson

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