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Application of magnetohydrodynamic actuation to continuous flow chemistry

Application of magnetohydrodynamic actuation to continuous flow chemistry
Application of magnetohydrodynamic actuation to continuous flow chemistry
Continuous flow microreactors with an annular microchannel for cyclical chemical reactions were fabricated by either bulk micromachining in silicon or by rapid prototyping using EPON SU-8. Fluid propulsion in these unusual microchannels was achieved using AC magnetohydrodynamic (MHD) actuation. This integrated micropumping mechanism obviates the use of moving parts by acting locally on the electrolyte, exploiting its inherent conductive nature. Both silicon and SU-8 microreactors were capable of MHD actuation, attaining fluid velocities of the order of 300 mum s(-1) when using a 500 mM KCl electrolyte. The polymerase chain reaction (PCR), a thermocycling process, was chosen as an illustrative example of a cyclical chemistry. Accordingly, temperature zones were provided to enable a thermal cycle during each revolution. With this approach, fluid velocity determines cycle duration. Here, we report device fabrication and performance, a model to accurately describe fluid circulation by MHD actuation, and compatibility issues relating to this approach to chemistry.
capillary electrophoresis, micro reactors, amplification, microreactor, photoresist
1473-0197
224-230
West, J.
f1c2e060-16c3-44c0-af70-242a1c58b968
Karamata, B.
c07d2b73-a3b5-4f3e-a848-611045a65a2f
Lillis, B.
f469ffb9-e4d5-409f-8026-937b93cefc0b
Gleeson, J.P.
39072555-99f4-4a3e-bdb2-9634aeff06d5
Alderman, J.
9b9d56b3-8d96-4f09-85f2-ac6343427c85
Collins, J.K.
5b1439ca-39c7-41cd-a99f-328d91bb4119
Lane, W.
0b9a4c80-493c-42a6-a207-777f9501943a
Mathewson, A.
12ebc78c-cdc9-4636-955a-a48e643e73c6
Berney, H.
bea83ffc-cbf9-4211-8d7a-4f0f7c9f87c5
West, J.
f1c2e060-16c3-44c0-af70-242a1c58b968
Karamata, B.
c07d2b73-a3b5-4f3e-a848-611045a65a2f
Lillis, B.
f469ffb9-e4d5-409f-8026-937b93cefc0b
Gleeson, J.P.
39072555-99f4-4a3e-bdb2-9634aeff06d5
Alderman, J.
9b9d56b3-8d96-4f09-85f2-ac6343427c85
Collins, J.K.
5b1439ca-39c7-41cd-a99f-328d91bb4119
Lane, W.
0b9a4c80-493c-42a6-a207-777f9501943a
Mathewson, A.
12ebc78c-cdc9-4636-955a-a48e643e73c6
Berney, H.
bea83ffc-cbf9-4211-8d7a-4f0f7c9f87c5

West, J., Karamata, B., Lillis, B., Gleeson, J.P., Alderman, J., Collins, J.K., Lane, W., Mathewson, A. and Berney, H. (2002) Application of magnetohydrodynamic actuation to continuous flow chemistry. Lab on a Chip, 2 (4), 224-230. (doi:10.1039/B206756K).

Record type: Article

Abstract

Continuous flow microreactors with an annular microchannel for cyclical chemical reactions were fabricated by either bulk micromachining in silicon or by rapid prototyping using EPON SU-8. Fluid propulsion in these unusual microchannels was achieved using AC magnetohydrodynamic (MHD) actuation. This integrated micropumping mechanism obviates the use of moving parts by acting locally on the electrolyte, exploiting its inherent conductive nature. Both silicon and SU-8 microreactors were capable of MHD actuation, attaining fluid velocities of the order of 300 mum s(-1) when using a 500 mM KCl electrolyte. The polymerase chain reaction (PCR), a thermocycling process, was chosen as an illustrative example of a cyclical chemistry. Accordingly, temperature zones were provided to enable a thermal cycle during each revolution. With this approach, fluid velocity determines cycle duration. Here, we report device fabrication and performance, a model to accurately describe fluid circulation by MHD actuation, and compatibility issues relating to this approach to chemistry.

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More information

Published date: 2002
Additional Information: ISI Document Delivery No.: 617XG Times Cited: 76 Cited Reference Count: 31 West, J Karamata, B Lillis, B Gleeson, JP Alderman, J Collins, JK Lane, W Mathewson, A Berney, H Royal soc chemistry Cambridge
Keywords: capillary electrophoresis, micro reactors, amplification, microreactor, photoresist
Organisations: Cancer Sciences

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Local EPrints ID: 346427
URI: https://eprints.soton.ac.uk/id/eprint/346427
ISSN: 1473-0197
PURE UUID: 6ba28fdf-6e03-48c8-93e0-fe88a0012685

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Date deposited: 25 Feb 2013 16:37
Last modified: 18 Jul 2017 05:04

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Contributors

Author: J. West
Author: B. Karamata
Author: B. Lillis
Author: J.P. Gleeson
Author: J. Alderman
Author: J.K. Collins
Author: W. Lane
Author: A. Mathewson
Author: H. Berney

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