Massively parallel production of lipid microstructures

West, J., Manz, A. and Dittrich, P.S. (2008) Massively parallel production of lipid microstructures. Lab on a Chip, 8 (11), 1852-1855. (doi:10.1039/B811448J).

Record type: Article

Abstract

In this paper we describe a simple and inexpensive microfluidic system for the production of lipid tubules and vesicles. The system incorporates a central microporous membrane for interfacing lipid. films with aqueous flows. Hydrodynamic drag was used for the parallel elongation of high axial ratio lipid tubules with uniform 1.5 +/- 0.5 mu m diameters. Alternatively, electrokinetic operation was used for the rapid and continuous production of vast numbers of lipid vesicles with diameters ranging from 1 to 3 mu m.

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Published date: 3 October 2008

Additional Information: ISI Document Delivery No.: 383PS Times Cited: 6 Cited Reference Count: 22 West, Jonathan Manz, Andreas Dittrich, Petra S. European Community [NMP4-CT-2004-500039]; European Research Council [203428]; Ministerium fur Innovation; Wissenschaft; Forschung und Technologie des Landes Nordrhein-Westfalen; Bundesministerium fur Bildung und Forschung The authors gratefully acknowledge Maria Becker for SEM analysis, Peter Jacob for support with EOF research and Joachim Franzke for valuable discussions. The research was made possible by financial support from the European Community (Cell PROM project, contract no. NMP4-CT-2004-500039) under the 6th Framework Programme and the European Research Council (ERC Starting Grant n mu-LIPIDS, project no. 203428). Funding by the Ministerium fur Innovation, Wissenschaft, Forschung und Technologie des Landes Nordrhein-Westfalen and by the Bundesministerium fur Bildung und Forschung is also gratefully acknowledged. Royal soc chemistry Cambridge

Keywords: nanotube-vesicle networks, tubules, surfactant membranes, molecules, growth

Organisations: Cancer Sciences