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Massively parallel production of lipid microstructures

Massively parallel production of lipid microstructures
Massively parallel production of lipid microstructures
In this paper we describe a simple and inexpensive microfluidic system for the production of lipid tubules and vesicles. The system incorporates a central microporous membrane for interfacing lipid. films with aqueous flows. Hydrodynamic drag was used for the parallel elongation of high axial ratio lipid tubules with uniform 1.5 +/- 0.5 mu m diameters. Alternatively, electrokinetic operation was used for the rapid and continuous production of vast numbers of lipid vesicles with diameters ranging from 1 to 3 mu m.
nanotube-vesicle networks, tubules, surfactant membranes, molecules, growth
1473-0197
1852-1855
West, J.
f1c2e060-16c3-44c0-af70-242a1c58b968
Manz, A.
d8d789e5-7066-4583-81f2-9d0410d3bbdc
Dittrich, P.S.
597cfaf1-f37c-4304-9dab-503183138d20
West, J.
f1c2e060-16c3-44c0-af70-242a1c58b968
Manz, A.
d8d789e5-7066-4583-81f2-9d0410d3bbdc
Dittrich, P.S.
597cfaf1-f37c-4304-9dab-503183138d20

West, J., Manz, A. and Dittrich, P.S. (2008) Massively parallel production of lipid microstructures. Lab on a Chip, 8 (11), 1852-1855. (doi:10.1039/B811448J).

Record type: Article

Abstract

In this paper we describe a simple and inexpensive microfluidic system for the production of lipid tubules and vesicles. The system incorporates a central microporous membrane for interfacing lipid. films with aqueous flows. Hydrodynamic drag was used for the parallel elongation of high axial ratio lipid tubules with uniform 1.5 +/- 0.5 mu m diameters. Alternatively, electrokinetic operation was used for the rapid and continuous production of vast numbers of lipid vesicles with diameters ranging from 1 to 3 mu m.

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More information

Published date: 3 October 2008
Additional Information: ISI Document Delivery No.: 383PS Times Cited: 6 Cited Reference Count: 22 West, Jonathan Manz, Andreas Dittrich, Petra S. European Community [NMP4-CT-2004-500039]; European Research Council [203428]; Ministerium fur Innovation; Wissenschaft; Forschung und Technologie des Landes Nordrhein-Westfalen; Bundesministerium fur Bildung und Forschung The authors gratefully acknowledge Maria Becker for SEM analysis, Peter Jacob for support with EOF research and Joachim Franzke for valuable discussions. The research was made possible by financial support from the European Community (Cell PROM project, contract no. NMP4-CT-2004-500039) under the 6th Framework Programme and the European Research Council (ERC Starting Grant n mu-LIPIDS, project no. 203428). Funding by the Ministerium fur Innovation, Wissenschaft, Forschung und Technologie des Landes Nordrhein-Westfalen and by the Bundesministerium fur Bildung und Forschung is also gratefully acknowledged. Royal soc chemistry Cambridge
Keywords: nanotube-vesicle networks, tubules, surfactant membranes, molecules, growth
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 346441
URI: http://eprints.soton.ac.uk/id/eprint/346441
ISSN: 1473-0197
PURE UUID: 7edb0d97-9c47-418d-8b8b-255849fd108d
ORCID for J. West: ORCID iD orcid.org/0000-0002-5709-6790

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Date deposited: 28 Jan 2013 11:04
Last modified: 15 Mar 2024 03:43

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Contributors

Author: J. West ORCID iD
Author: A. Manz
Author: P.S. Dittrich

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