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The placental origins of sudden cardiac death

The placental origins of sudden cardiac death
The placental origins of sudden cardiac death
Objective: most sudden cardiac deaths are due to cardiac arrhythmias, and abnormalities in the autonomic nervous system could underlie them. There is growing evidence that coronary heart disease is associated with alterations of fetal development as a result of variations in the processes of placentation that control fetal nutrition.
We hypothesized that placental size would be associated with
sudden cardiac death.

Methods: we examined sudden cardiac death within the Helsinki Birth Cohort of 13 345 men and women.

Results: one hundred eighty-seven (2.7%) men and 47 (0.7%) women had sudden unexplained cardiac death outside hospital. Sudden death was associated with a thin placenta, the hazard ratio being 1.47[95% confidence interval (CI) 1.11–1.93, P¼0.006] for each g/cm2 decrease in thickness. Sudden death was independently associated with poor educational attainment (P<0.0001). Both of these associations were independent of socio-economic status in later life.

Conclusion: sudden death may be initiated by impaired development of the autonomic nervous system in utero as a result of shallow invasion of the spiral arteries in the maternal endometrium and consequent fetal malnutrition
sudden cardiac death, placenta, educational attainment
0300-5771
1394-1399
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Larsen, Gail
61056010-5594-4c37-9294-24f521e89dd1
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Thornburg, Kent, L.
60c828a4-5f41-4fb9-afd8-54dcbcab11de
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Larsen, Gail
61056010-5594-4c37-9294-24f521e89dd1
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Thornburg, Kent, L.
60c828a4-5f41-4fb9-afd8-54dcbcab11de
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac

Barker, David J.P., Larsen, Gail, Osmond, Clive, Thornburg, Kent, L., Kajantie, Eero and Eriksson, Johan G. (2012) The placental origins of sudden cardiac death. International Journal of Epidemiology, 41 (5), 1394-1399. (PMID:22997261)

Record type: Article

Abstract

Objective: most sudden cardiac deaths are due to cardiac arrhythmias, and abnormalities in the autonomic nervous system could underlie them. There is growing evidence that coronary heart disease is associated with alterations of fetal development as a result of variations in the processes of placentation that control fetal nutrition.
We hypothesized that placental size would be associated with
sudden cardiac death.

Methods: we examined sudden cardiac death within the Helsinki Birth Cohort of 13 345 men and women.

Results: one hundred eighty-seven (2.7%) men and 47 (0.7%) women had sudden unexplained cardiac death outside hospital. Sudden death was associated with a thin placenta, the hazard ratio being 1.47[95% confidence interval (CI) 1.11–1.93, P¼0.006] for each g/cm2 decrease in thickness. Sudden death was independently associated with poor educational attainment (P<0.0001). Both of these associations were independent of socio-economic status in later life.

Conclusion: sudden death may be initiated by impaired development of the autonomic nervous system in utero as a result of shallow invasion of the spiral arteries in the maternal endometrium and consequent fetal malnutrition

Full text not available from this repository.

More information

e-pub ahead of print date: 19 September 2012
Published date: October 2012
Keywords: sudden cardiac death, placenta, educational attainment
Organisations: Faculty of Medicine, Faculty of Health Sciences

Identifiers

Local EPrints ID: 346496
URI: https://eprints.soton.ac.uk/id/eprint/346496
ISSN: 0300-5771
PURE UUID: 3b6216b8-e858-4a67-9d62-aad8c3329f4f
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 04 Jan 2013 13:30
Last modified: 06 Jun 2018 13:04

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