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Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environment

Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environment
Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environment
Microreactors have been shown to be a powerful tool for the production of nanoparticles (NPs); however, there is still a lack of understanding of the role that the microfluidic environment plays in directing the nanoprecipitation process. Here we investigate the mechanism of nanoprecipitation of block copolymer stabilized organic NPs using a microfluidic-based reactor in combination with computational fluid dynamics (CFD) modelling of the microfluidic implementation. The latter also accounts for the complex interplay between molecular and hydrodynamic phenomena during the nanoprecipitation process, in order to understand the hydrodynamics and its influence on the NP formation process. It is demonstrated that the competitive reactions result in the formation of two types of NPs, i.e., either with or without loading organic actives. The obtained results are interpreted by taking into consideration a new parameter representing the mismatching between the aggregations of the polymers and actives, which plays a decisive role in determining the size and polydispersity of the prepared hybrid NPs. These results expand the current understanding of the co-nanoprecipitation mechanism of active and block copolymer stabilizer, and on the role exerted by the microfluidic environment, giving information that could be translated to the emerging fields of microfluidic formation of NPs and nanomedicine
0957-4484
375602
Capretto, Lorenzo
d4bb501b-c4b8-4a2a-8830-21d3f884f75d
Cheng, Wei
ea96edaa-0e7f-4c5b-aae4-838d4cb32664
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Katsamenis, Orestis L.
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Capretto, Lorenzo
d4bb501b-c4b8-4a2a-8830-21d3f884f75d
Cheng, Wei
ea96edaa-0e7f-4c5b-aae4-838d4cb32664
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Katsamenis, Orestis L.
8553e7c3-d860-4b7a-a883-abf6c0c4b438
Hill, Martyn
0cda65c8-a70f-476f-b126-d2c4460a253e
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1

Capretto, Lorenzo, Cheng, Wei, Carugo, Dario, Katsamenis, Orestis L., Hill, Martyn and Zhang, Xunli (2012) Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environment. Nanotechnology, 23 (37), 375602. (doi:10.1088/0957-4484/23/37/375602).

Record type: Article

Abstract

Microreactors have been shown to be a powerful tool for the production of nanoparticles (NPs); however, there is still a lack of understanding of the role that the microfluidic environment plays in directing the nanoprecipitation process. Here we investigate the mechanism of nanoprecipitation of block copolymer stabilized organic NPs using a microfluidic-based reactor in combination with computational fluid dynamics (CFD) modelling of the microfluidic implementation. The latter also accounts for the complex interplay between molecular and hydrodynamic phenomena during the nanoprecipitation process, in order to understand the hydrodynamics and its influence on the NP formation process. It is demonstrated that the competitive reactions result in the formation of two types of NPs, i.e., either with or without loading organic actives. The obtained results are interpreted by taking into consideration a new parameter representing the mismatching between the aggregations of the polymers and actives, which plays a decisive role in determining the size and polydispersity of the prepared hybrid NPs. These results expand the current understanding of the co-nanoprecipitation mechanism of active and block copolymer stabilizer, and on the role exerted by the microfluidic environment, giving information that could be translated to the emerging fields of microfluidic formation of NPs and nanomedicine

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Published date: 24 August 2012
Organisations: Bioengineering Group, Southampton Education School, Mechatronics

Identifiers

Local EPrints ID: 346514
URI: https://eprints.soton.ac.uk/id/eprint/346514
ISSN: 0957-4484
PURE UUID: 7bec5058-80ab-4fc7-ad4e-cc3bf0040cd3
ORCID for Orestis L. Katsamenis: ORCID iD orcid.org/0000-0003-4367-4147
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448

Catalogue record

Date deposited: 04 Jan 2013 11:42
Last modified: 06 Jun 2018 13:12

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