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Oscillation dynamics of embolic microspheres in flows with red blood cell suspensions

Oscillation dynamics of embolic microspheres in flows with red blood cell suspensions
Oscillation dynamics of embolic microspheres in flows with red blood cell suspensions
Dynamic nature of particle motion in blood flow is an important determinant of embolization based cancer therapy. Yet, the manner in which the presence of high volume fraction of red blood cells influences the particle dynamics remains unknown. Here, by investigating the motions of embolic microspheres in pressure-driven flows of red blood cell suspensions through capillaries, we illustrate unique oscillatory trends in particle trajectories, which are not observable in Newtonian fluid flows. Our investigation reveals that such oscillatory behavior essentially manifests when three simultaneous conditions, namely, the Reynolds number beyond a threshold limit, degree of confinement beyond a critical limit, and high hematocrit level, are fulfilled simultaneously. Given that these conditions are extremely relevant to fluid dynamics of blood or polymer flow, the observations reported here bear significant implications on embolization based cancer treatment as well as for complex multiphase fluidics involving particles
0021-8979
124701-[7pp]
Das, Tamal
3e8768f2-fd09-495e-9bee-44f5340aa7d7
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Chakraborty, Suman
3683eef7-e86e-43a0-91f0-22826c9f4da6
Das, Tamal
3e8768f2-fd09-495e-9bee-44f5340aa7d7
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Chakraborty, Suman
3683eef7-e86e-43a0-91f0-22826c9f4da6

Das, Tamal, Carugo, Dario, Zhang, Xunli and Chakraborty, Suman (2012) Oscillation dynamics of embolic microspheres in flows with red blood cell suspensions. Journal of Applied Physics, 112 (12), 124701-[7pp]. (doi:10.1063/1.4768889).

Record type: Article

Abstract

Dynamic nature of particle motion in blood flow is an important determinant of embolization based cancer therapy. Yet, the manner in which the presence of high volume fraction of red blood cells influences the particle dynamics remains unknown. Here, by investigating the motions of embolic microspheres in pressure-driven flows of red blood cell suspensions through capillaries, we illustrate unique oscillatory trends in particle trajectories, which are not observable in Newtonian fluid flows. Our investigation reveals that such oscillatory behavior essentially manifests when three simultaneous conditions, namely, the Reynolds number beyond a threshold limit, degree of confinement beyond a critical limit, and high hematocrit level, are fulfilled simultaneously. Given that these conditions are extremely relevant to fluid dynamics of blood or polymer flow, the observations reported here bear significant implications on embolization based cancer treatment as well as for complex multiphase fluidics involving particles

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Published date: December 2012
Organisations: Bioengineering Group

Identifiers

Local EPrints ID: 346515
URI: https://eprints.soton.ac.uk/id/eprint/346515
ISSN: 0021-8979
PURE UUID: 871dbd38-4d94-47b6-9161-033f09b1ffed
ORCID for Xunli Zhang: ORCID iD orcid.org/0000-0002-4375-1571

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Date deposited: 04 Jan 2013 15:06
Last modified: 22 Sep 2019 00:34

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