The University of Southampton
University of Southampton Institutional Repository

Biologically defined risk groups can be used to define the impact of thalidomide maintenance therapy in newly diagnosed multiple myeloma

Biologically defined risk groups can be used to define the impact of thalidomide maintenance therapy in newly diagnosed multiple myeloma
Biologically defined risk groups can be used to define the impact of thalidomide maintenance therapy in newly diagnosed multiple myeloma
Maintenance therapy is an attractive strategy for Multiple Myeloma patients. However the impact of maintenance thalidomide according to the underlying biology of the disease is still a matter of debate, with some studies suggesting that thalidomide is more beneficial in high risk disease, whilst others show the opposite. Biological risk groups defined by interphase fluorescence in situ hybridisation (FISH) are powerful predictors of outcome. In this report we investigated the effect of maintenance thalidomide in different biological risk groups defined by different FISH categories. Our data show that maintenance thalidomide improves outcome in patients with biologically low risk disease, defined by the absence of adverse cytogenetic lesion or by the presence of hyperdiploidy alone. Conversely thalidomide maintenance is detrimental for overall survival of patients with biological high risk. We conclude that it is important to identify biologically low risk patients that will benefit from a maintenance strategy with thalidomide


1042-8194
1975-1981
Brioli, Annamaria
ce12e6b5-d90f-40fa-b81c-2610534a2418
Kaiser, Martin F.
06cc69df-57a7-405d-abc8-06a6ae1cdc78
Pawlyn, Charlotte
aaf950bf-819c-43bb-93e0-edc498e7c409
Wu, Ping
bb7ce9c2-d7a0-4e52-b28a-5699391e9bc2
Gregory, Walter M.
4a7a4c5a-0a88-4ba2-8f08-0c035dd0b6db
Owen, Roger
d485f150-ba07-4b3d-8f6f-dd4c1cfbc37e
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Jackson, Graham H.
82e8cc2d-7530-4b02-8f92-176f47451839
Cavo, Michele
d50df96d-22b2-4596-84a0-220b2e918942
Davies, Faith E.
9ea9e143-ac51-431b-8cb5-57b8dc0a38af
Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939
Brioli, Annamaria
ce12e6b5-d90f-40fa-b81c-2610534a2418
Kaiser, Martin F.
06cc69df-57a7-405d-abc8-06a6ae1cdc78
Pawlyn, Charlotte
aaf950bf-819c-43bb-93e0-edc498e7c409
Wu, Ping
bb7ce9c2-d7a0-4e52-b28a-5699391e9bc2
Gregory, Walter M.
4a7a4c5a-0a88-4ba2-8f08-0c035dd0b6db
Owen, Roger
d485f150-ba07-4b3d-8f6f-dd4c1cfbc37e
Ross, Fiona M.
ec0958f8-b992-4e4a-b7e3-c474600390ba
Jackson, Graham H.
82e8cc2d-7530-4b02-8f92-176f47451839
Cavo, Michele
d50df96d-22b2-4596-84a0-220b2e918942
Davies, Faith E.
9ea9e143-ac51-431b-8cb5-57b8dc0a38af
Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939

Brioli, Annamaria, Kaiser, Martin F., Pawlyn, Charlotte, Wu, Ping, Gregory, Walter M., Owen, Roger, Ross, Fiona M., Jackson, Graham H., Cavo, Michele, Davies, Faith E. and Morgan, Gareth J. (2013) Biologically defined risk groups can be used to define the impact of thalidomide maintenance therapy in newly diagnosed multiple myeloma. Leukemia and Lymphoma, 54 (9), 1975-1981. (doi:10.3109/10428194.2012.760736). (PMID:23270579)

Record type: Article

Abstract

Maintenance therapy is an attractive strategy for Multiple Myeloma patients. However the impact of maintenance thalidomide according to the underlying biology of the disease is still a matter of debate, with some studies suggesting that thalidomide is more beneficial in high risk disease, whilst others show the opposite. Biological risk groups defined by interphase fluorescence in situ hybridisation (FISH) are powerful predictors of outcome. In this report we investigated the effect of maintenance thalidomide in different biological risk groups defined by different FISH categories. Our data show that maintenance thalidomide improves outcome in patients with biologically low risk disease, defined by the absence of adverse cytogenetic lesion or by the presence of hyperdiploidy alone. Conversely thalidomide maintenance is detrimental for overall survival of patients with biological high risk. We conclude that it is important to identify biologically low risk patients that will benefit from a maintenance strategy with thalidomide


Full text not available from this repository.

More information

e-pub ahead of print date: 28 December 2012
Published date: September 2013
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 346606
URI: https://eprints.soton.ac.uk/id/eprint/346606
ISSN: 1042-8194
PURE UUID: 2fa64e67-10f5-4e57-88af-ce211de112dd

Catalogue record

Date deposited: 03 Jan 2013 11:32
Last modified: 18 Jul 2017 05:03

Export record

Altmetrics

Contributors

Author: Annamaria Brioli
Author: Martin F. Kaiser
Author: Charlotte Pawlyn
Author: Ping Wu
Author: Walter M. Gregory
Author: Roger Owen
Author: Fiona M. Ross
Author: Graham H. Jackson
Author: Michele Cavo
Author: Faith E. Davies
Author: Gareth J. Morgan

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×