MicroRNAs and respiratory diseases
MicroRNAs and respiratory diseases
MicroRNAs (miRNA) are a family of endogenous, small, noncoding RNA molecules that modulate physiological and pathological processes by post-transcriptional inhibition of gene expression. They were first recognised as regulators of development in worms and fruitflies. In recent years extensive research has explored their pivotal role in the pathogenesis of human diseases. Over 1000 human miRNAs have been discovered to date, however the biological function and protein targets for the majority remain to be uncovered. Within the respiratory system, miRNAs are important in normal pulmonary development and maintaining lung homeostasis. Recent studies have also begun to reveal that altered miRNA expression profiles may be associated with pathological processes within the lung and lead to the development of various pulmonary diseases ranging from inflammatory diseases to lung cancers. Advancing our understanding of the role of miRNAs in the respiratory system will help provide new perspectives on disease mechanisms and reveal intriguing therapeutic targets and diagnostics for respiratory disorders.
adaptive immune response, asthma, cigarette smoke, innate immune response, lung cancer, microRNA regulation
695-705
Rupani, Hitasha
ed650f59-d273-46e9-ac34-0cd179f494ca
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
28 February 2013
Rupani, Hitasha
ed650f59-d273-46e9-ac34-0cd179f494ca
Sanchez-Elsner, Tilman
b8799f8d-e2b4-4b37-b77c-f2f0e8e2070d
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Abstract
MicroRNAs (miRNA) are a family of endogenous, small, noncoding RNA molecules that modulate physiological and pathological processes by post-transcriptional inhibition of gene expression. They were first recognised as regulators of development in worms and fruitflies. In recent years extensive research has explored their pivotal role in the pathogenesis of human diseases. Over 1000 human miRNAs have been discovered to date, however the biological function and protein targets for the majority remain to be uncovered. Within the respiratory system, miRNAs are important in normal pulmonary development and maintaining lung homeostasis. Recent studies have also begun to reveal that altered miRNA expression profiles may be associated with pathological processes within the lung and lead to the development of various pulmonary diseases ranging from inflammatory diseases to lung cancers. Advancing our understanding of the role of miRNAs in the respiratory system will help provide new perspectives on disease mechanisms and reveal intriguing therapeutic targets and diagnostics for respiratory disorders.
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e-pub ahead of print date: 12 July 2012
Published date: 28 February 2013
Keywords:
adaptive immune response, asthma, cigarette smoke, innate immune response, lung cancer, microRNA regulation
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 346653
URI: http://eprints.soton.ac.uk/id/eprint/346653
ISSN: 0903-1936
PURE UUID: f54bb669-662d-4368-906e-c7cbfc9308d1
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Date deposited: 08 Jan 2013 13:46
Last modified: 15 Mar 2024 03:29
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Author:
Hitasha Rupani
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