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Severe chronic allergic (and related) diseases: a uniform approach - a MeDALL-GA2LEN-ARIA position paper

Severe chronic allergic (and related) diseases: a uniform approach - a MeDALL-GA2LEN-ARIA position paper
Severe chronic allergic (and related) diseases: a uniform approach - a MeDALL-GA2LEN-ARIA position paper
Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
immunoglobulin e, asthma, rhinitis, rhinosinusitis, urticaria, atopic dermatitis
1018-2438
216-231
Bousquet, J.
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Anto, J.M.
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Demoly, P.
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Schünemann, H.J.
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Togias, A.
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Akdis, M.
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Bousquet, P.J.
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Carlsen, K.H
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Casale, T.B.
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Basagaña, X.
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Cesario, A.
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Morais-Almeida, M.
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Palkonen, S.
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Passalacqua, G.
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Pawankar, R.
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Pison, C.
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Roberts, R.
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Roca, J.
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Rogala, B.
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Romano, A.
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Rosado-Pinto, J.
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Ryan, D.
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Sanchez-Borges, M.
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Scadding, G.K.
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Sheikh, A.
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Simons, F.E.R.
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Zuberbier, T.
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Bousquet, J., Anto, J.M., Demoly, P., Schünemann, H.J., Togias, A., Akdis, M., Auffray, C., Bachert, C., Bieber, T., Bousquet, P.J., Carlsen, K.H, Casale, T.B., Cruz, A.A., Keil, T., Lodrup Carlsen, K.C., Maurer, M., Ohta, K., Papadopoulos, N.G., Roman Rodriguez, M., Samolinski, B., Agache, I., Andrianarisoa, A., Ang, C.S., Annesi-Maesano, I., Ballester, F., Baena-Cagnani, C.E., Basagaña, X., Bateman, E.D., Bel, E.H., Bedbrook, A., Beghé, B., Beji, M., Ben Kheder, A., Benet, M., Bennoor, K.S., Bergmann, K.C., Berrissoul, F., Bindslev Jensen, C., Bleecker, E.R., Bonini, S., Boner, A.L., Boulet, L.P., Brightling, C.E., Brozek, J.L., Bush, A., Busse, W.W., Camargos, P.A.M., Canonica, G.W., Carr, W., Cesario, A., Chen, Y.Z., Chiriac, A.M., Costa, D.J., Cox, L., Custovic, A., Dahl, R., Darsow, U., Didi, T., Dolen, W.K., Douagui, H., Dubakiene, R., El-Meziane, A., Fonseca, J.A., Fokkens, W.J., Fthenou, E., Gamkrelidze, A., Garcia-Aymerich, J., Gerth van Wijk, R., Gimeno-Santos, E., Guerra, S., Haahtela, T., Haddad, H., Hellings, P.W., Hellquist-Dahl, B., Hohmann, C., Howarth, P., Hourihane, J.O., Humbert, M., Jacquemin, B., Just, J., Kalayci, O., Kaliner, M.A., Kauffmann, F., Kerkhof, M., Khayat, G., Koffi N'Goran, B., Kogevinas, M., Koppelman, G.H., Kowalski, M.L., Kull, I., Kuna, P., Larenas, D., Lavi, I., Le, L.T., Lieberman, P., Lipworth, B., Mahboub, B., Makela, M.J., Martin, F., Martinez, F.D., Marshall, G.D., Mazon, A., Melen, E., Meltzer, E.O., Mihaltan, F., Mohammad, Y., Mohammadi, A., Momas, I., Morais-Almeida, M., Mullol, J., Muraro, A., Naclerio, R., Nafti, S., Namazova-Baranova, L., Nawijn, M.C., Nyembue, T.D., Oddie, S., O'Hehir, R.E., Okamoto, Y., Orru, M.P., Ozdemir, C., Ouedraogo, G.S., Palkonen, S., Panzner, P., Passalacqua, G., Pawankar, R., Pigearias, B., Pin, I., Pinart, M., Pison, C., Popov, T.A., Porta, D., Postma, D.S., Price, D., Rabe, K.F., Ratomaharo, J., Reitamo, S., Rezagui, D., Ring, J., Roberts, R., Roca, J., Rogala, B., Romano, A., Rosado-Pinto, J., Ryan, D., Sanchez-Borges, M., Scadding, G.K., Sheikh, A., Simons, F.E.R., Siroux, V., Schmid-Grendelmeier, P.D., Smit, H.A., Sooronbaev, T., Stein, R.T., Sterk, P.J., Sunyer, J., Terreehorst, I., Toskala, E., Tremblay, Y., Valenta, R., Valeyre, D., Vandenplas, O., van Weel, C., Vassilaki, M., Varraso, R., Viegi, G., Wang, D.Y., Wickman, M., Williams, D., Wöhrl, S., Wright, J., Yorgancioglu, A., Yusuf, O.M., Zar, H.J., Zernotti, M.E., Zidarn, M., Zhong, N. and Zuberbier, T. (2012) Severe chronic allergic (and related) diseases: a uniform approach - a MeDALL-GA2LEN-ARIA position paper. International Archives of Allergy and Immunology, 158 (3), 216-231. (doi:10.1159/000332924). (PMID:22382913)

Record type: Article

Abstract

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.

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Published date: 1 March 2012
Keywords: immunoglobulin e, asthma, rhinitis, rhinosinusitis, urticaria, atopic dermatitis
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 346688
URI: https://eprints.soton.ac.uk/id/eprint/346688
ISSN: 1018-2438
PURE UUID: fb4ccaf0-7165-4842-8454-43b675a90ff5

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Date deposited: 16 Jan 2013 13:40
Last modified: 18 Jul 2017 05:02

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Contributors

Author: J. Bousquet
Author: J.M. Anto
Author: P. Demoly
Author: H.J. Schünemann
Author: A. Togias
Author: M. Akdis
Author: C. Auffray
Author: C. Bachert
Author: T. Bieber
Author: P.J. Bousquet
Author: K.H Carlsen
Author: T.B. Casale
Author: A.A. Cruz
Author: T. Keil
Author: K.C. Lodrup Carlsen
Author: M. Maurer
Author: K. Ohta
Author: N.G. Papadopoulos
Author: M. Roman Rodriguez
Author: B. Samolinski
Author: I. Agache
Author: A. Andrianarisoa
Author: C.S. Ang
Author: I. Annesi-Maesano
Author: F. Ballester
Author: C.E. Baena-Cagnani
Author: X. Basagaña
Author: E.D. Bateman
Author: E.H. Bel
Author: A. Bedbrook
Author: B. Beghé
Author: M. Beji
Author: A. Ben Kheder
Author: M. Benet
Author: K.S. Bennoor
Author: K.C. Bergmann
Author: F. Berrissoul
Author: C. Bindslev Jensen
Author: E.R. Bleecker
Author: S. Bonini
Author: A.L. Boner
Author: L.P. Boulet
Author: C.E. Brightling
Author: J.L. Brozek
Author: A. Bush
Author: W.W. Busse
Author: P.A.M. Camargos
Author: G.W. Canonica
Author: W. Carr
Author: A. Cesario
Author: Y.Z. Chen
Author: A.M. Chiriac
Author: D.J. Costa
Author: L. Cox
Author: A. Custovic
Author: R. Dahl
Author: U. Darsow
Author: T. Didi
Author: W.K. Dolen
Author: H. Douagui
Author: R. Dubakiene
Author: A. El-Meziane
Author: J.A. Fonseca
Author: W.J. Fokkens
Author: E. Fthenou
Author: A. Gamkrelidze
Author: J. Garcia-Aymerich
Author: R. Gerth van Wijk
Author: E. Gimeno-Santos
Author: S. Guerra
Author: T. Haahtela
Author: H. Haddad
Author: P.W. Hellings
Author: B. Hellquist-Dahl
Author: C. Hohmann
Author: P. Howarth
Author: J.O. Hourihane
Author: M. Humbert
Author: B. Jacquemin
Author: J. Just
Author: O. Kalayci
Author: M.A. Kaliner
Author: F. Kauffmann
Author: M. Kerkhof
Author: G. Khayat
Author: B. Koffi N'Goran
Author: M. Kogevinas
Author: G.H. Koppelman
Author: M.L. Kowalski
Author: I. Kull
Author: P. Kuna
Author: D. Larenas
Author: I. Lavi
Author: L.T. Le
Author: P. Lieberman
Author: B. Lipworth
Author: B. Mahboub
Author: M.J. Makela
Author: F. Martin
Author: F.D. Martinez
Author: G.D. Marshall
Author: A. Mazon
Author: E. Melen
Author: E.O. Meltzer
Author: F. Mihaltan
Author: Y. Mohammad
Author: A. Mohammadi
Author: I. Momas
Author: M. Morais-Almeida
Author: J. Mullol
Author: A. Muraro
Author: R. Naclerio
Author: S. Nafti
Author: L. Namazova-Baranova
Author: M.C. Nawijn
Author: T.D. Nyembue
Author: S. Oddie
Author: R.E. O'Hehir
Author: Y. Okamoto
Author: M.P. Orru
Author: C. Ozdemir
Author: G.S. Ouedraogo
Author: S. Palkonen
Author: P. Panzner
Author: G. Passalacqua
Author: R. Pawankar
Author: B. Pigearias
Author: I. Pin
Author: M. Pinart
Author: C. Pison
Author: T.A. Popov
Author: D. Porta
Author: D.S. Postma
Author: D. Price
Author: K.F. Rabe
Author: J. Ratomaharo
Author: S. Reitamo
Author: D. Rezagui
Author: J. Ring
Author: R. Roberts
Author: J. Roca
Author: B. Rogala
Author: A. Romano
Author: J. Rosado-Pinto
Author: D. Ryan
Author: M. Sanchez-Borges
Author: G.K. Scadding
Author: A. Sheikh
Author: F.E.R. Simons
Author: V. Siroux
Author: P.D. Schmid-Grendelmeier
Author: H.A. Smit
Author: T. Sooronbaev
Author: R.T. Stein
Author: P.J. Sterk
Author: J. Sunyer
Author: I. Terreehorst
Author: E. Toskala
Author: Y. Tremblay
Author: R. Valenta
Author: D. Valeyre
Author: O. Vandenplas
Author: C. van Weel
Author: M. Vassilaki
Author: R. Varraso
Author: G. Viegi
Author: D.Y. Wang
Author: M. Wickman
Author: D. Williams
Author: S. Wöhrl
Author: J. Wright
Author: A. Yorgancioglu
Author: O.M. Yusuf
Author: H.J. Zar
Author: M.E. Zernotti
Author: M. Zidarn
Author: N. Zhong
Author: T. Zuberbier

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