Anti-adhesion methods as novel therapeutics for bacterial infections
Anti-adhesion methods as novel therapeutics for bacterial infections
Anti-adhesion therapies for bacterial infections offer an alternative to antibiotics, with those therapies bacteria are not killed but are prevented from causing harm to a host by inhibiting adherence to host cells and tissues, a prerequisite for the majority of infectious diseases. The mechanisms of these potential therapeutic agents include inhibition of adhesins and their host receptors, vaccination with adhesins or analogs, use of probiotics and dietary supplements that interfere with receptor-adhesin interactions, subminimal inhibitory concentrations of antibiotics and manipulation of hydrophobic interactions. Once developed, these drugs will contribute to the arsenal for fighting infectious disease in the future, potentially subverting antibiotic resistance.
1457-1468
Cozens, Daniel
9d9ad74b-c574-49e8-be62-e6e0b04c81ac
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
December 2012
Cozens, Daniel
9d9ad74b-c574-49e8-be62-e6e0b04c81ac
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Cozens, Daniel and Read, Robert C.
(2012)
Anti-adhesion methods as novel therapeutics for bacterial infections.
Expert Review of Anti-Infective Therapy, 10 (12), .
(doi:10.1586/eri.12.145).
(PMID:23253323)
Abstract
Anti-adhesion therapies for bacterial infections offer an alternative to antibiotics, with those therapies bacteria are not killed but are prevented from causing harm to a host by inhibiting adherence to host cells and tissues, a prerequisite for the majority of infectious diseases. The mechanisms of these potential therapeutic agents include inhibition of adhesins and their host receptors, vaccination with adhesins or analogs, use of probiotics and dietary supplements that interfere with receptor-adhesin interactions, subminimal inhibitory concentrations of antibiotics and manipulation of hydrophobic interactions. Once developed, these drugs will contribute to the arsenal for fighting infectious disease in the future, potentially subverting antibiotic resistance.
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Published date: December 2012
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 346726
URI: http://eprints.soton.ac.uk/id/eprint/346726
ISSN: 1744-8336
PURE UUID: 63c98594-f2ec-4bbb-b1b8-ddfb50d6e70f
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Date deposited: 16 Jan 2013 13:07
Last modified: 15 Mar 2024 03:42
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Author:
Daniel Cozens
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