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Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data

Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data
Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data
Triage tools have an important role in pandemics to identify those most likely to benefit from higher levels of care. We compared Community Assessment Tools (CATs), the CURB-65 score, and the Pandemic Medical Early Warning Score (PMEWS); to predict higher levels of care (high dependency--Level 2 or intensive care--Level 3) and/or death in patients at or shortly after admission to hospital with A/H1N1 2009 pandemic influenza. This was a case-control analysis using retrospectively collected data from the FLU-CIN cohort (1040 adults, 480 children) with PCR-confirmed A/H1N1 2009 influenza. Area under receiver operator curves (AUROC), sensitivity, specificity, positive predictive values and negative predictive values were calculated. CATs best predicted Level 2/3 admissions in both adults [AUROC (95% CI): CATs 0.77 (0.73, 0.80); CURB-65 0.68 (0.64, 0.72); PMEWS 0.68 (0.64, 0.73), p<0.001] and children [AUROC: CATs 0.74 (0.68, 0.80); CURB-65 0.52 (0.46, 0.59); PMEWS 0.69 (0.62, 0.75), p<0.001]. CURB-65 and CATs were similar in predicting death in adults with both performing better than PMEWS; and CATs best predicted death in children. CATs were the best predictor of Level 2/3 care and/or death for both adults and children. CATs are potentially useful triage tools for predicting need for higher levels of care and/or mortality in patients of all ages.
1932-6203
e34428
Myles, Puja R.
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Nguyen-Van-Tam, Jonathan S.
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Lim, Wei Shen
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Nicholson, Karl G.
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Brett, Stephen J.
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Enstone, Joanne E.
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McMenamin, James
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Openshaw, Peter J.M.
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Read, Robert C.
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Taylor, Bruce L.
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Bannister, Barbara
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Semple, Malcolm G.
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Myles, Puja R.
123c952c-b5b3-47bf-8e67-1d50bb40b114
Nguyen-Van-Tam, Jonathan S.
1aac2164-f614-4c82-87f9-e123817bf128
Lim, Wei Shen
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Nicholson, Karl G.
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Brett, Stephen J.
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Enstone, Joanne E.
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McMenamin, James
d152729c-4145-4ee1-8fe2-838ae5f02604
Openshaw, Peter J.M.
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Read, Robert C.
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Taylor, Bruce L.
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Bannister, Barbara
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Semple, Malcolm G.
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Myles, Puja R., Nguyen-Van-Tam, Jonathan S., Lim, Wei Shen, Nicholson, Karl G., Brett, Stephen J., Enstone, Joanne E., McMenamin, James, Openshaw, Peter J.M., Read, Robert C., Taylor, Bruce L., Bannister, Barbara and Semple, Malcolm G. (2012) Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data. PLoS ONE, 7 (4), e34428. (doi:10.1371/journal.pone.0034428). (PMID:22509303)

Record type: Article

Abstract

Triage tools have an important role in pandemics to identify those most likely to benefit from higher levels of care. We compared Community Assessment Tools (CATs), the CURB-65 score, and the Pandemic Medical Early Warning Score (PMEWS); to predict higher levels of care (high dependency--Level 2 or intensive care--Level 3) and/or death in patients at or shortly after admission to hospital with A/H1N1 2009 pandemic influenza. This was a case-control analysis using retrospectively collected data from the FLU-CIN cohort (1040 adults, 480 children) with PCR-confirmed A/H1N1 2009 influenza. Area under receiver operator curves (AUROC), sensitivity, specificity, positive predictive values and negative predictive values were calculated. CATs best predicted Level 2/3 admissions in both adults [AUROC (95% CI): CATs 0.77 (0.73, 0.80); CURB-65 0.68 (0.64, 0.72); PMEWS 0.68 (0.64, 0.73), p<0.001] and children [AUROC: CATs 0.74 (0.68, 0.80); CURB-65 0.52 (0.46, 0.59); PMEWS 0.69 (0.62, 0.75), p<0.001]. CURB-65 and CATs were similar in predicting death in adults with both performing better than PMEWS; and CATs best predicted death in children. CATs were the best predictor of Level 2/3 care and/or death for both adults and children. CATs are potentially useful triage tools for predicting need for higher levels of care and/or mortality in patients of all ages.

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Published date: April 2012
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 346743
URI: http://eprints.soton.ac.uk/id/eprint/346743
ISSN: 1932-6203
PURE UUID: 847cb26f-59ac-4804-9450-0ab4d4608830
ORCID for Robert C. Read: ORCID iD orcid.org/0000-0002-4297-6728

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Date deposited: 23 Jan 2013 12:05
Last modified: 15 Mar 2024 03:42

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Contributors

Author: Puja R. Myles
Author: Jonathan S. Nguyen-Van-Tam
Author: Wei Shen Lim
Author: Karl G. Nicholson
Author: Stephen J. Brett
Author: Joanne E. Enstone
Author: James McMenamin
Author: Peter J.M. Openshaw
Author: Robert C. Read ORCID iD
Author: Bruce L. Taylor
Author: Barbara Bannister
Author: Malcolm G. Semple

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