Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.
Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.
Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels. The mechanism of this relative loss of humoral protection remains undetermined. In this report we have investigated the relationship between T- and B-cell activation and co-stimulation and the loss of protective antibody titers. We have found that healthy volunteers who lose protective MenC antibody levels one year after receipt of glycoconjugate vaccine exhibit no detectable cellular defect in polyclonal B- or T-cell activation, proliferation or the B-memory pool. This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation.
e31160
Wing, James B.
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Smart, Lynne
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Borrow, Ray
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Findlow, Jamie
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Findlow, Helen
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Lees, Andrew
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Read, Robert C.
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Heath, Andrew W.
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2012
Wing, James B.
f1e7db81-a229-4386-87ea-f58dd0e8519a
Smart, Lynne
e307ff61-93e1-43a1-9b74-4344cec1796b
Borrow, Ray
45e5fda9-8300-486e-89ca-323f3ae9c9a6
Findlow, Jamie
8580c790-262c-4fc5-99bc-0beddaef98a0
Findlow, Helen
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Lees, Andrew
dba4db52-3b05-4414-a801-e3255d068b67
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Heath, Andrew W.
303a3623-9848-4b85-add7-880752386f0d
Wing, James B., Smart, Lynne, Borrow, Ray, Findlow, Jamie, Findlow, Helen, Lees, Andrew, Read, Robert C. and Heath, Andrew W.
(2012)
Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.
PLoS ONE, 7 (2), .
(doi:10.1371/journal.pone.0031160).
(PMID:22347446)
Abstract
Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels. The mechanism of this relative loss of humoral protection remains undetermined. In this report we have investigated the relationship between T- and B-cell activation and co-stimulation and the loss of protective antibody titers. We have found that healthy volunteers who lose protective MenC antibody levels one year after receipt of glycoconjugate vaccine exhibit no detectable cellular defect in polyclonal B- or T-cell activation, proliferation or the B-memory pool. This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation.
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Published date: 2012
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 346745
URI: http://eprints.soton.ac.uk/id/eprint/346745
ISSN: 1932-6203
PURE UUID: 911ccd5c-3e04-4790-bc09-14640fc24d1c
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Date deposited: 23 Jan 2013 12:01
Last modified: 15 Mar 2024 03:42
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Author:
James B. Wing
Author:
Lynne Smart
Author:
Ray Borrow
Author:
Jamie Findlow
Author:
Helen Findlow
Author:
Andrew Lees
Author:
Andrew W. Heath
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