Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics
Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics
Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.
463-467
Darton, Tom C.
42f166dc-3b5f-4709-b818-de22424e8fc7
Guiver, Malcolm
a4a2ae54-a47b-48b4-86ff-7ffa374a8013
Naylor, Simone
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Kaczmarski, Edward B.
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Borrow, Raymond
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Read, Robert C.
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September 2011
Darton, Tom C.
42f166dc-3b5f-4709-b818-de22424e8fc7
Guiver, Malcolm
a4a2ae54-a47b-48b4-86ff-7ffa374a8013
Naylor, Simone
d368bae4-ed68-4652-bf0c-9ce9bbd84d5f
Kaczmarski, Edward B.
b64d93b8-aaee-44f6-a7a3-715f8971d3b3
Borrow, Raymond
dd28679e-2072-4639-9d68-851ada2eeea3
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Darton, Tom C., Guiver, Malcolm, Naylor, Simone, Kaczmarski, Edward B., Borrow, Raymond and Read, Robert C.
(2011)
Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics.
Clinical Infectious Diseases, 53 (5), .
(doi:10.1093/cid/cir433).
(PMID:21798855)
Abstract
Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads.
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Published date: September 2011
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 346749
URI: http://eprints.soton.ac.uk/id/eprint/346749
ISSN: 1058-4838
PURE UUID: a4c565d2-37c7-4df4-8d2a-b39006e5ab08
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Date deposited: 28 Jan 2013 13:43
Last modified: 15 Mar 2024 03:42
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Contributors
Author:
Tom C. Darton
Author:
Malcolm Guiver
Author:
Simone Naylor
Author:
Edward B. Kaczmarski
Author:
Raymond Borrow
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