Adult survivors of invasive pneumococcal disease exhibit defective B cell function
Adult survivors of invasive pneumococcal disease exhibit defective B cell function
Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to ??-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.
1133-1136
Darton, Tom C.
42f166dc-3b5f-4709-b818-de22424e8fc7
Wing, James B.
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Lees, Andrew
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Heath, Andrew W.
303a3623-9848-4b85-add7-880752386f0d
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
May 2011
Darton, Tom C.
42f166dc-3b5f-4709-b818-de22424e8fc7
Wing, James B.
f1e7db81-a229-4386-87ea-f58dd0e8519a
Lees, Andrew
dba4db52-3b05-4414-a801-e3255d068b67
Heath, Andrew W.
303a3623-9848-4b85-add7-880752386f0d
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Darton, Tom C., Wing, James B., Lees, Andrew, Heath, Andrew W. and Read, Robert C.
(2011)
Adult survivors of invasive pneumococcal disease exhibit defective B cell function.
Clinical Infectious Diseases, 52 (9), .
(doi:10.1093/cid/cir126).
(PMID:21467018)
Abstract
Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to ??-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.
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Published date: May 2011
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 346757
URI: http://eprints.soton.ac.uk/id/eprint/346757
ISSN: 1058-4838
PURE UUID: 43c9f1a3-335a-4570-9ee0-82f6f8c24abf
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Date deposited: 29 Jan 2013 10:14
Last modified: 15 Mar 2024 03:42
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Author:
Tom C. Darton
Author:
James B. Wing
Author:
Andrew Lees
Author:
Andrew W. Heath
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