Challenges for development of meningococcal vaccines in infants and children
Challenges for development of meningococcal vaccines in infants and children
Neisseria meningitidis causes significant disease in the form of severe sepsis syndrome or meningococcal meningitis. Owing to the susceptibility of the immune system in early life, the risk of disease after infection is significantly higher in infants. Thus far, vaccines targeted against meningococcal serogroups have struggled to provide lasting protection in young children. Even conjugate vaccines that are now routinely used in the immunization of infants require multiple dosing and the duration of protection has been shown to wane over time and require repeated booster doses. After briefly summarizing the current epidemiology according to age and serogroup, this article will consider the reasons for poor immunogenicity of vaccines in infants and will discuss the relative efficacy of the different vaccine types in this age group. It will then go on to consider strategies for optimizing the protection of infants against meningococcal disease.
335-343
Deasy, Alice
f562217d-2aa7-40af-9bf7-4e5a0a30c112
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
March 2011
Deasy, Alice
f562217d-2aa7-40af-9bf7-4e5a0a30c112
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Deasy, Alice and Read, Robert C.
(2011)
Challenges for development of meningococcal vaccines in infants and children.
Expert Review of Vaccines, 10 (3), .
(doi:10.1586/erv.11.3).
(PMID:21434801)
Abstract
Neisseria meningitidis causes significant disease in the form of severe sepsis syndrome or meningococcal meningitis. Owing to the susceptibility of the immune system in early life, the risk of disease after infection is significantly higher in infants. Thus far, vaccines targeted against meningococcal serogroups have struggled to provide lasting protection in young children. Even conjugate vaccines that are now routinely used in the immunization of infants require multiple dosing and the duration of protection has been shown to wane over time and require repeated booster doses. After briefly summarizing the current epidemiology according to age and serogroup, this article will consider the reasons for poor immunogenicity of vaccines in infants and will discuss the relative efficacy of the different vaccine types in this age group. It will then go on to consider strategies for optimizing the protection of infants against meningococcal disease.
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Published date: March 2011
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 346759
URI: http://eprints.soton.ac.uk/id/eprint/346759
ISSN: 1476-0584
PURE UUID: 1e7cfff5-0f3b-4b1e-a409-6a86b91c8996
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Date deposited: 29 Jan 2013 12:16
Last modified: 15 Mar 2024 03:42
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Author:
Alice Deasy
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