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A systematic review of hip fracture incidence and probability of fracture worldwide

A systematic review of hip fracture incidence and probability of fracture worldwide
A systematic review of hip fracture incidence and probability of fracture worldwide
Summary: the country-specific risk of hip fracture and the 10-year probability of a major osteoporotic fracture were determined on a worldwide basis from a systematic review of literature. There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries.

Introduction: the present study aimed to update the available information base available on the heterogeneity in the risk of hip fracture on a worldwide basis. An additional aim was to document variations in major fracture probability as determined from the available FRAX models.

Methods: studies on hip fracture risk were identified from 1950 to November 2011 by a Medline OVID search. Evaluable studies in each country were reviewed for quality and representativeness and a study (studies) chosen to represent that country. Age-specific incidence rates were age-standardised to the world population in 2010 in men, women and both sexes combined. The 10-year probability of a major osteoporotic fracture for a specific clinical scenario was computed in those countries for which a FRAX model was available.

Results: following quality evaluation, age-standardised rates of hip fracture were available for 63 countries and 45 FRAX models available in 40 countries to determine fracture probability. There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries.

Conclusions: worldwide, there are marked variations in hip fracture rates and in the 10-year probability of major osteoporotic fractures. The variation is sufficiently large that these cannot be explained by the often multiple sources of error in the ascertainment of cases or the catchment population. Understanding the reasons for this heterogeneity may lead to global strategies for the prevention of fractures
0937-941X
2239-2256
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Oden, A.
c018cdda-62cd-44a0-be3a-227484a568bb
McCloskey, E.V.
38518227-db8f-4a53-88a6-462f469151de
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Wahl, D.A.
32cf9afd-a852-4818-aad2-e6fb29443059
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Oden, A.
c018cdda-62cd-44a0-be3a-227484a568bb
McCloskey, E.V.
38518227-db8f-4a53-88a6-462f469151de
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Wahl, D.A.
32cf9afd-a852-4818-aad2-e6fb29443059
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Kanis, J.A., Oden, A., McCloskey, E.V., Johansson, H., Wahl, D.A. and Cooper, C. (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporosis International, 23 (9), 2239-2256. (doi:10.1007/s00198-012-1964-3). (PMID:22419370)

Record type: Article

Abstract

Summary: the country-specific risk of hip fracture and the 10-year probability of a major osteoporotic fracture were determined on a worldwide basis from a systematic review of literature. There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries.

Introduction: the present study aimed to update the available information base available on the heterogeneity in the risk of hip fracture on a worldwide basis. An additional aim was to document variations in major fracture probability as determined from the available FRAX models.

Methods: studies on hip fracture risk were identified from 1950 to November 2011 by a Medline OVID search. Evaluable studies in each country were reviewed for quality and representativeness and a study (studies) chosen to represent that country. Age-specific incidence rates were age-standardised to the world population in 2010 in men, women and both sexes combined. The 10-year probability of a major osteoporotic fracture for a specific clinical scenario was computed in those countries for which a FRAX model was available.

Results: following quality evaluation, age-standardised rates of hip fracture were available for 63 countries and 45 FRAX models available in 40 countries to determine fracture probability. There was a greater than 10-fold variation in hip fracture risk and fracture probability between countries.

Conclusions: worldwide, there are marked variations in hip fracture rates and in the 10-year probability of major osteoporotic fractures. The variation is sufficiently large that these cannot be explained by the often multiple sources of error in the ascertainment of cases or the catchment population. Understanding the reasons for this heterogeneity may lead to global strategies for the prevention of fractures

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Published date: September 2012
Organisations: Faculty of Medicine, Faculty of Health Sciences

Identifiers

Local EPrints ID: 346811
URI: http://eprints.soton.ac.uk/id/eprint/346811
ISSN: 0937-941X
PURE UUID: a5dcb24c-5e94-4981-b314-9e93bf39958b
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 10 Jan 2013 14:55
Last modified: 17 Dec 2019 01:56

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