The University of Southampton
University of Southampton Institutional Repository

Effect of maternal body mass index on the retinal microvasculature in pregnancy

Effect of maternal body mass index on the retinal microvasculature in pregnancy
Effect of maternal body mass index on the retinal microvasculature in pregnancy
OBJECTIVE: To estimate the effects of maternal body mass index (BMI) and pregnancy weight gain on the retinal microvasculature among pregnant women.

METHODS: We studied 814 pregnant women aged 18–46 years who were recruited as part of the Growing Up in Singapore Toward Health Outcomes study, an ongoing birth cohort study from two government hospitals in Singapore since 2009. Recalled prepregnancy weight was recorded, and maternal anthropometric measurements of weight and height were performed at 26 weeks of gestation together with retinal photography.

RESULTS: In multiple linear regression models, each standard deviation increase of 26-week pregnancy BMI (4.57) was associated with narrower retinal arteriolar caliber (by 1.58 micrometers, P<.001), wider venular caliber (by 1.28 micrometers, P=.02), and increased retinal venular tortuosity (P=.01). Compared with mothers with normal weight, obese mothers (prepregnancy BMI greater than 30.0) had narrower retinal arteriolar caliber (118.81 compared with 123.38 micrometers, P<.001), wider retinal venular caliber (175.81 compared with 173.01 micrometers; P<.01), and increased retinal venular tortuosity (129.92 compared with 121.49×10?6; P<.01). Pregnant women whose BMI-specific weight gain from prepregnancy to 26 weeks of gestation was above Institute of Medicine recommendations had narrower retinal arteriolar caliber (120.68 micrometers) than women with ideal (121.91 micrometers) and less than ideal weight gain (123.17), respectively (Ptrend=.05).

CONCLUSION: These data indicate that greater prepregnancy BMI and pregnancy BMI are associated with adverse retinal microvascular measures, suggesting that maternal obesity has an effect on her microcirculation.
0009-9201
627-635
Li, L.J.
1b806dc9-1796-4626-ad83-d70e7efea9a9
Ikram, M.K.
4a537013-6bc2-4284-a367-af63a4601558
Cheung, C.Y.
cfdf6af4-ab3c-40de-a7d8-4657f549c056
Lee, Y.S.
829a41bb-945c-49cd-ad12-0f3d9c2782c6
Lee, L.J.
046c0690-990e-4cf1-98a9-8c6d18973e9f
Gluckman, P.
dadc86d4-4eaa-4589-b560-413a9e564558
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Kwek, K.
1a9b6c6e-a5e9-40a2-9bfe-44c2cea62a98
Wong, T.Y.
4e780510-7814-40f8-bda4-9e833f9f7593
Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Li, L.J.
1b806dc9-1796-4626-ad83-d70e7efea9a9
Ikram, M.K.
4a537013-6bc2-4284-a367-af63a4601558
Cheung, C.Y.
cfdf6af4-ab3c-40de-a7d8-4657f549c056
Lee, Y.S.
829a41bb-945c-49cd-ad12-0f3d9c2782c6
Lee, L.J.
046c0690-990e-4cf1-98a9-8c6d18973e9f
Gluckman, P.
dadc86d4-4eaa-4589-b560-413a9e564558
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Chong, Y.S.
b50c99c9-4d83-46c5-a1c7-23f9a553ab8a
Kwek, K.
1a9b6c6e-a5e9-40a2-9bfe-44c2cea62a98
Wong, T.Y.
4e780510-7814-40f8-bda4-9e833f9f7593
Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd

Li, L.J., Ikram, M.K., Cheung, C.Y., Lee, Y.S., Lee, L.J., Gluckman, P., Godfrey, K.M., Chong, Y.S., Kwek, K., Wong, T.Y. and Saw, S.M. (2012) Effect of maternal body mass index on the retinal microvasculature in pregnancy. Clinical Obstetrics & Gynecology, 120 (3), 627-635. (doi:10.1097/AOG.0b013e3182639577). (PMID:22914473)

Record type: Article

Abstract

OBJECTIVE: To estimate the effects of maternal body mass index (BMI) and pregnancy weight gain on the retinal microvasculature among pregnant women.

METHODS: We studied 814 pregnant women aged 18–46 years who were recruited as part of the Growing Up in Singapore Toward Health Outcomes study, an ongoing birth cohort study from two government hospitals in Singapore since 2009. Recalled prepregnancy weight was recorded, and maternal anthropometric measurements of weight and height were performed at 26 weeks of gestation together with retinal photography.

RESULTS: In multiple linear regression models, each standard deviation increase of 26-week pregnancy BMI (4.57) was associated with narrower retinal arteriolar caliber (by 1.58 micrometers, P<.001), wider venular caliber (by 1.28 micrometers, P=.02), and increased retinal venular tortuosity (P=.01). Compared with mothers with normal weight, obese mothers (prepregnancy BMI greater than 30.0) had narrower retinal arteriolar caliber (118.81 compared with 123.38 micrometers, P<.001), wider retinal venular caliber (175.81 compared with 173.01 micrometers; P<.01), and increased retinal venular tortuosity (129.92 compared with 121.49×10?6; P<.01). Pregnant women whose BMI-specific weight gain from prepregnancy to 26 weeks of gestation was above Institute of Medicine recommendations had narrower retinal arteriolar caliber (120.68 micrometers) than women with ideal (121.91 micrometers) and less than ideal weight gain (123.17), respectively (Ptrend=.05).

CONCLUSION: These data indicate that greater prepregnancy BMI and pregnancy BMI are associated with adverse retinal microvascular measures, suggesting that maternal obesity has an effect on her microcirculation.

This record has no associated files available for download.

More information

Published date: September 2012
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 346859
URI: http://eprints.soton.ac.uk/id/eprint/346859
ISSN: 0009-9201
PURE UUID: 055c601d-3f4b-47bc-8927-243cc751254f
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 11 Jan 2013 11:37
Last modified: 15 Mar 2024 02:43

Export record

Altmetrics

Contributors

Author: L.J. Li
Author: M.K. Ikram
Author: C.Y. Cheung
Author: Y.S. Lee
Author: L.J. Lee
Author: P. Gluckman
Author: K.M. Godfrey ORCID iD
Author: Y.S. Chong
Author: K. Kwek
Author: T.Y. Wong
Author: S.M. Saw

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×