The University of Southampton
University of Southampton Institutional Repository

Male breast cancer, age and sex chromosome aneuploidy

Male breast cancer, age and sex chromosome aneuploidy
Male breast cancer, age and sex chromosome aneuploidy
Background: In cultured, dividing transformed T lymphocytes and in dividing bone marrow cells from normal men and those with a haematological malignancy, sex chromosome aneuploidy has been found to increase in prevalence and degree with age. This has rarely been investigated in non-dividing uncultured blood samples. The loss and gain of the X chromosome in dividing transformed lymphocytes in women with age is much more frequent than that of the Y chromosome in males. However, paradoxically X chromosome aneuploidy is rarely seen in the dividing cells of bone marrow of females.
Methods: In blood samples from 565 men with breast cancer and 54 control men from the England and Wales general population, 80 cell nuclei per sample were scored for presence of X and Y chromosomes using fluorescent centromeric probes.
Results: Sex chromosome aneuploidy, largely Y chromosome loss, was present in 63% of cases and 57% of controls, with the prevalence and degree of aneuploidy increasingly sharply and highly significantly with age. At ages 65–80 years, 71% of cases and 85% of controls showed aneuploidy and 15% and 25%, respectively, had X10% of cells aneuploid. Allowing for age, aneuploidy was less prevalent (P¼0.03) in cases than controls.
Conclusion: Sex chromosome aneuploidy in non-dividing nuclei of peripheral blood cells is frequent in adult men, the prevalence and degree increasing sharply with age. The possible relation of sex chromosome aneuploidy to breast cancer risk in men, and to cancer risk generally, needs further investigation, ideally in cohort studies.
male breast cancer, sex chromosome aneuploidy, age
0007-0920
959-963
Jacobs, P. A.
b266ce7f-f74a-4480-9923-23109bb1b63f
Maloney, V.
07e33c11-8048-490b-b93f-ae53f878d002
Cooke, R.
3eb69d42-c21d-429f-aaf8-0e4d9e289a4f
Crolla, J A
c5f23751-8de9-4a55-9cc5-ca2fb635769c
Ashworth, A.
298ff6ed-9870-42da-8e6d-d9980308296d
Swerdlow, A. J.
b32fe09f-d5e3-444f-a731-ae82eed2f281
Jacobs, P. A.
b266ce7f-f74a-4480-9923-23109bb1b63f
Maloney, V.
07e33c11-8048-490b-b93f-ae53f878d002
Cooke, R.
3eb69d42-c21d-429f-aaf8-0e4d9e289a4f
Crolla, J A
c5f23751-8de9-4a55-9cc5-ca2fb635769c
Ashworth, A.
298ff6ed-9870-42da-8e6d-d9980308296d
Swerdlow, A. J.
b32fe09f-d5e3-444f-a731-ae82eed2f281

Jacobs, P. A., Maloney, V., Cooke, R., Crolla, J A, Ashworth, A. and Swerdlow, A. J. (2013) Male breast cancer, age and sex chromosome aneuploidy. British Journal of Cancer, 108 (4), 959-963. (doi:10.1038/bjc.2012.577). (PMID:23299533)

Record type: Article

Abstract

Background: In cultured, dividing transformed T lymphocytes and in dividing bone marrow cells from normal men and those with a haematological malignancy, sex chromosome aneuploidy has been found to increase in prevalence and degree with age. This has rarely been investigated in non-dividing uncultured blood samples. The loss and gain of the X chromosome in dividing transformed lymphocytes in women with age is much more frequent than that of the Y chromosome in males. However, paradoxically X chromosome aneuploidy is rarely seen in the dividing cells of bone marrow of females.
Methods: In blood samples from 565 men with breast cancer and 54 control men from the England and Wales general population, 80 cell nuclei per sample were scored for presence of X and Y chromosomes using fluorescent centromeric probes.
Results: Sex chromosome aneuploidy, largely Y chromosome loss, was present in 63% of cases and 57% of controls, with the prevalence and degree of aneuploidy increasingly sharply and highly significantly with age. At ages 65–80 years, 71% of cases and 85% of controls showed aneuploidy and 15% and 25%, respectively, had X10% of cells aneuploid. Allowing for age, aneuploidy was less prevalent (P¼0.03) in cases than controls.
Conclusion: Sex chromosome aneuploidy in non-dividing nuclei of peripheral blood cells is frequent in adult men, the prevalence and degree increasing sharply with age. The possible relation of sex chromosome aneuploidy to breast cancer risk in men, and to cancer risk generally, needs further investigation, ideally in cohort studies.

This record has no associated files available for download.

More information

e-pub ahead of print date: 8 January 2013
Published date: 5 March 2013
Keywords: male breast cancer, sex chromosome aneuploidy, age
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 346874
URI: http://eprints.soton.ac.uk/id/eprint/346874
ISSN: 0007-0920
PURE UUID: 9433bc8d-356a-4d63-becf-30564cf7ea83

Catalogue record

Date deposited: 11 Jan 2013 12:45
Last modified: 22 Jul 2022 18:19

Export record

Altmetrics

Contributors

Author: P. A. Jacobs
Author: V. Maloney
Author: R. Cooke
Author: J A Crolla
Author: A. Ashworth
Author: A. J. Swerdlow

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×