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Anisotropic time-dependant behaviour of the aortic valve

Anisotropic time-dependant behaviour of the aortic valve
Anisotropic time-dependant behaviour of the aortic valve
The complex tri-layered structure of the aortic valve (AV) results in anisotropic quasi–static mechanical behaviour. However, its influence on AV viscoelasticity remains poorly understood. Viscoelasticity may strongly influence AV dynamic mechanical behaviour, making it essential to characterise the time-dependent response for designing successful substitutes. This study attempts to characterise the time-dependent behaviour of the AV at different strain and load increments, and to gain insight into the contribution of the microstructure to this behaviour. Uniaxial incremental stress-relaxation and creep experiments were undertaken, and the experimental data analysed with a generalised Maxwell model, to determine the characteristic time-dependent parameters. Results showed that the time dependent response of the tissue differed with the loading direction, and also with the level of applied load or strain, in both stress-relaxation and creep phenomena. Both phenomena were consistently more pronounced in the radial loading direction. Fitting of the Maxwell model highlighted that the time dependent modes required to model the data also varied in different increments, and additionally with the loading direction. These results suggest that different micro-structural mechanisms may be activated in stress-relaxation and creep, determined by the microstructural organisation of the valve matrix in each loading direction, at each strain or load increment.

1751-6161
1603-1610
Anssari-Benam, A.
4c643502-e3a2-411d-8bb0-fc7809f1d349
Bader, Dan L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Screen, H.R.C.
9aac879e-3d79-4466-892a-f8a3c5ef0bed
Anssari-Benam, A.
4c643502-e3a2-411d-8bb0-fc7809f1d349
Bader, Dan L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Screen, H.R.C.
9aac879e-3d79-4466-892a-f8a3c5ef0bed

Anssari-Benam, A., Bader, Dan L. and Screen, H.R.C. (2011) Anisotropic time-dependant behaviour of the aortic valve. Journal of the Mechanical Behavior of Biomedical Materials, 4 (8), 1603-1610. (doi:10.1016/j.jmbbm.2011.02.010). (PMID:22098862)

Record type: Article

Abstract

The complex tri-layered structure of the aortic valve (AV) results in anisotropic quasi–static mechanical behaviour. However, its influence on AV viscoelasticity remains poorly understood. Viscoelasticity may strongly influence AV dynamic mechanical behaviour, making it essential to characterise the time-dependent response for designing successful substitutes. This study attempts to characterise the time-dependent behaviour of the AV at different strain and load increments, and to gain insight into the contribution of the microstructure to this behaviour. Uniaxial incremental stress-relaxation and creep experiments were undertaken, and the experimental data analysed with a generalised Maxwell model, to determine the characteristic time-dependent parameters. Results showed that the time dependent response of the tissue differed with the loading direction, and also with the level of applied load or strain, in both stress-relaxation and creep phenomena. Both phenomena were consistently more pronounced in the radial loading direction. Fitting of the Maxwell model highlighted that the time dependent modes required to model the data also varied in different increments, and additionally with the loading direction. These results suggest that different micro-structural mechanisms may be activated in stress-relaxation and creep, determined by the microstructural organisation of the valve matrix in each loading direction, at each strain or load increment.

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More information

Published date: November 2011
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 347056
URI: https://eprints.soton.ac.uk/id/eprint/347056
ISSN: 1751-6161
PURE UUID: 8bfbe8ab-4ae3-40a5-b725-50be26ffd9cf
ORCID for Dan L. Bader: ORCID iD orcid.org/0000-0002-1208-3507

Catalogue record

Date deposited: 28 Jan 2013 14:57
Last modified: 06 Jun 2018 12:32

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