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Quantitative optical coherence tomography of fluid-filled oral mucosal lesions

Quantitative optical coherence tomography of fluid-filled oral mucosal lesions
Quantitative optical coherence tomography of fluid-filled oral mucosal lesions
The decision of selecting the most representative site for the biopsy of fluid-filled lesions can be difficult. This may be attributed to the poor delineation of the correct lesional site by clinical observation alone. In this study, optical coherence tomography is used to quantify the contrast between solid- and fluid-filled lesions by measuring the light intensity change at the tissue–fluid interface (intensity drop). This parameter was measured from sequential axial scans (n???106 per sample) of 3D optical coherence tomography (OCT) datasets from control tissues (n?=?14) and fluid-filled lesions (n?=?7) and displayed as a 2D-scaled intensity drop (SID) image. The results of the SID image allowed for discrimination, characterisation and extent of a fluid filled region. The differentiation of normal and fluid-filled areas using individual SID values yielded both a sensitivity and specificity of approximately 80 %. OCT complemented by SID analysis provides a potential in vivo clinical tool that would enable non-invasive objective visualisation of the oral mucosa
0268-8921
Adegun, O.K.
13356dde-f24f-49be-a460-aa8bfd47f290
Tomlins, P.H.
2f99ef97-cb74-4d83-ad84-3e591fb3f239
Hagi-Pavli, E.
46a5bc2b-6f99-4e0d-85e1-e6b91f190798
Bader, Dan L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Fortune, F.
3a85bb55-da22-4268-aa1e-7b5ba2d08355
Adegun, O.K.
13356dde-f24f-49be-a460-aa8bfd47f290
Tomlins, P.H.
2f99ef97-cb74-4d83-ad84-3e591fb3f239
Hagi-Pavli, E.
46a5bc2b-6f99-4e0d-85e1-e6b91f190798
Bader, Dan L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Fortune, F.
3a85bb55-da22-4268-aa1e-7b5ba2d08355

Adegun, O.K., Tomlins, P.H., Hagi-Pavli, E., Bader, Dan L. and Fortune, F. (2012) Quantitative optical coherence tomography of fluid-filled oral mucosal lesions. Lasers in Medical Science. (doi:10.1007/s10103-012-1208-y). (PMID:22996049)

Record type: Article

Abstract

The decision of selecting the most representative site for the biopsy of fluid-filled lesions can be difficult. This may be attributed to the poor delineation of the correct lesional site by clinical observation alone. In this study, optical coherence tomography is used to quantify the contrast between solid- and fluid-filled lesions by measuring the light intensity change at the tissue–fluid interface (intensity drop). This parameter was measured from sequential axial scans (n???106 per sample) of 3D optical coherence tomography (OCT) datasets from control tissues (n?=?14) and fluid-filled lesions (n?=?7) and displayed as a 2D-scaled intensity drop (SID) image. The results of the SID image allowed for discrimination, characterisation and extent of a fluid filled region. The differentiation of normal and fluid-filled areas using individual SID values yielded both a sensitivity and specificity of approximately 80 %. OCT complemented by SID analysis provides a potential in vivo clinical tool that would enable non-invasive objective visualisation of the oral mucosa

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More information

e-pub ahead of print date: 21 September 2012
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 347081
URI: https://eprints.soton.ac.uk/id/eprint/347081
ISSN: 0268-8921
PURE UUID: 65cfa031-acc0-469d-a181-9670dd70e1dc
ORCID for Dan L. Bader: ORCID iD orcid.org/0000-0002-1208-3507

Catalogue record

Date deposited: 17 Jan 2013 15:19
Last modified: 05 Nov 2019 01:41

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