Is there a bidirectional relationship between depressive symptoms and cognitive ability in older people?
Is there a bidirectional relationship between depressive symptoms and cognitive ability in older people?
Background: cross-sectional surveys of older people commonly find associations between higher levels of depressive symptoms and poorer cognitive performance, but the direction of effect is unclear. We examined whether there was a bidirectional relationship between depressive symptoms and general cognitive ability in non-demented older people, and explored the role of physical health, smoking, exercise, social class and education as potential confounders of this association and as possible determinants of the rate of change of cognitive decline and depressive symptoms.
Method: the English Longitudinal Study of Ageing consists of people aged 50 years and over. Cognitive function and self-reported depressive symptoms were measured in 2002–2003, 2004–2005, 2006–2007 and 2008–2009. We fitted linear piecewise models with fixed knot positions to allow different slopes for different age groups. Analyses are based on 8611 people.
Results: mean cognitive function declined with age; there was no trend in the trajectory of depressive symptoms. Better cognitive function was associated with less depression up to the age of 80 years. Greater depression was associated with a slightly faster rate of cognitive decline but only in people aged 60–80 years. There were no consistent associations across age groups between sex, smoking, education, social class, exercise or number of chronic physical illnesses and the rate of change of cognitive decline or depressive symptoms.
Conclusions: in this longitudinal study of older people, there was no consistent evidence that being more depressed led to an acceleration in cognitive decline and no support for the hypothesis that there might be reciprocal dynamic influences between cognitive ability and depressive symptoms
2057-2069
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Allerhand, M.
30b3123e-2d5e-40c3-b51b-c4bb38c951d7
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60
October 2012
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Allerhand, M.
30b3123e-2d5e-40c3-b51b-c4bb38c951d7
Deary, I.J.
e3403cfe-eb5b-4941-903d-87ef0db89c60
Gale, C.R., Allerhand, M. and Deary, I.J.
(2012)
Is there a bidirectional relationship between depressive symptoms and cognitive ability in older people?
Psychological Medicine, 42 (10), .
(doi:10.1017/S0033291712000402.).
(PMID:23206378)
Abstract
Background: cross-sectional surveys of older people commonly find associations between higher levels of depressive symptoms and poorer cognitive performance, but the direction of effect is unclear. We examined whether there was a bidirectional relationship between depressive symptoms and general cognitive ability in non-demented older people, and explored the role of physical health, smoking, exercise, social class and education as potential confounders of this association and as possible determinants of the rate of change of cognitive decline and depressive symptoms.
Method: the English Longitudinal Study of Ageing consists of people aged 50 years and over. Cognitive function and self-reported depressive symptoms were measured in 2002–2003, 2004–2005, 2006–2007 and 2008–2009. We fitted linear piecewise models with fixed knot positions to allow different slopes for different age groups. Analyses are based on 8611 people.
Results: mean cognitive function declined with age; there was no trend in the trajectory of depressive symptoms. Better cognitive function was associated with less depression up to the age of 80 years. Greater depression was associated with a slightly faster rate of cognitive decline but only in people aged 60–80 years. There were no consistent associations across age groups between sex, smoking, education, social class, exercise or number of chronic physical illnesses and the rate of change of cognitive decline or depressive symptoms.
Conclusions: in this longitudinal study of older people, there was no consistent evidence that being more depressed led to an acceleration in cognitive decline and no support for the hypothesis that there might be reciprocal dynamic influences between cognitive ability and depressive symptoms
This record has no associated files available for download.
More information
e-pub ahead of print date: March 2012
Published date: October 2012
Organisations:
Faculty of Medicine
Identifiers
Local EPrints ID: 347104
URI: http://eprints.soton.ac.uk/id/eprint/347104
ISSN: 0033-2917
PURE UUID: ee9d7a1a-54b7-4124-a1a9-e09138c0842a
Catalogue record
Date deposited: 17 Jan 2013 09:50
Last modified: 15 Mar 2024 02:49
Export record
Altmetrics
Contributors
Author:
M. Allerhand
Author:
I.J. Deary
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics