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XPac dissimilarity parameters as quantitative descriptors of isostructurality: the case of fourteen 4,5?-substituted benzenesulfonamido-2-pyridines obtained by substituent interchange involving CF3/I/Br/Cl/F/Me/H

XPac dissimilarity parameters as quantitative descriptors of isostructurality: the case of fourteen 4,5?-substituted benzenesulfonamido-2-pyridines obtained by substituent interchange involving CF3/I/Br/Cl/F/Me/H
XPac dissimilarity parameters as quantitative descriptors of isostructurality: the case of fourteen 4,5?-substituted benzenesulfonamido-2-pyridines obtained by substituent interchange involving CF3/I/Br/Cl/F/Me/H
Crystal structures of fourteen 4,5'-substituted benzenesulfonamido-2-pyridines, with tautomeric forms R-1-C6H4-SO2-N=C5NH4-R-2 or R-1-C6H4-SO2-NH-C5NH3-R-2, and with R-1 = CF3, I, Br, Cl, Me, F, H and R-2 = CF3 or I are reported. Comparisons carried out with the program XPac show that all investigated structures display a common 3D arrangement of N-H center dot center dot center dot N bonded centrosymmetric dimers. This isostructural series is exceptional in its completeness and in the diversity of the substituents involved. Accordingly, the XPac dissimilarity index x, a measure of how far two structures deviate from perfect geometrical similarity, varies from 0.9 for the interchange R-1 = Br -> Cl to 9.5 for the simultaneous interchange of R-1 = I -> H and R-2 = CF3 -> I. XPac plots of individual dissimilarity parameters have been used to elucidate details of geometrical similarities and differences between structures. This indicated that the geometry is preserved most closely within bc-layers that are composed of 1D slipped stacks of N-H center dot center dot center dot N bonded dimers, with interlayer van der Waals interactions being dominated by R-1 center dot center dot center dot R-2 contacts. The main mode of geometrical adjustment for the size of R-1 is a parallel shift of neighbouring layers against one another in the direction perpendicular to the layer plane, whilst the relative orientations of molecules within each layer are altered to a much smaller extent, even for those structure pairs representing R-1 substituents that are very different in size. This study shows that the ability of two compounds to crystallise in fundamentally the same crystal structure depends not only on how much their molecules differ in shape but also, critically, on the specific tolerance characteristics of the crystal packing arrangement concerned. As a comparison with the present study, dissimilarity indices are reported for a set of 24 isostructural 4,4'-substituted benzenesulfonamidobenzenes previously subjected to XPac analysis.
1466-8033
5454-5464
Gelbrich, Thomas
42309d69-eaf1-4bb7-ba2e-db61f338e370
Threlfall, Terence L.
dc1fe3b2-c0c1-465c-942f-dbd4af68a37e
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
Gelbrich, Thomas
42309d69-eaf1-4bb7-ba2e-db61f338e370
Threlfall, Terence L.
dc1fe3b2-c0c1-465c-942f-dbd4af68a37e
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da

Gelbrich, Thomas, Threlfall, Terence L. and Hursthouse, Michael B. (2012) XPac dissimilarity parameters as quantitative descriptors of isostructurality: the case of fourteen 4,5?-substituted benzenesulfonamido-2-pyridines obtained by substituent interchange involving CF3/I/Br/Cl/F/Me/H. CrystEngComm, 14 (17), 5454-5464. (doi:10.1039/c2ce25508a).

Record type: Article

Abstract

Crystal structures of fourteen 4,5'-substituted benzenesulfonamido-2-pyridines, with tautomeric forms R-1-C6H4-SO2-N=C5NH4-R-2 or R-1-C6H4-SO2-NH-C5NH3-R-2, and with R-1 = CF3, I, Br, Cl, Me, F, H and R-2 = CF3 or I are reported. Comparisons carried out with the program XPac show that all investigated structures display a common 3D arrangement of N-H center dot center dot center dot N bonded centrosymmetric dimers. This isostructural series is exceptional in its completeness and in the diversity of the substituents involved. Accordingly, the XPac dissimilarity index x, a measure of how far two structures deviate from perfect geometrical similarity, varies from 0.9 for the interchange R-1 = Br -> Cl to 9.5 for the simultaneous interchange of R-1 = I -> H and R-2 = CF3 -> I. XPac plots of individual dissimilarity parameters have been used to elucidate details of geometrical similarities and differences between structures. This indicated that the geometry is preserved most closely within bc-layers that are composed of 1D slipped stacks of N-H center dot center dot center dot N bonded dimers, with interlayer van der Waals interactions being dominated by R-1 center dot center dot center dot R-2 contacts. The main mode of geometrical adjustment for the size of R-1 is a parallel shift of neighbouring layers against one another in the direction perpendicular to the layer plane, whilst the relative orientations of molecules within each layer are altered to a much smaller extent, even for those structure pairs representing R-1 substituents that are very different in size. This study shows that the ability of two compounds to crystallise in fundamentally the same crystal structure depends not only on how much their molecules differ in shape but also, critically, on the specific tolerance characteristics of the crystal packing arrangement concerned. As a comparison with the present study, dissimilarity indices are reported for a set of 24 isostructural 4,4'-substituted benzenesulfonamidobenzenes previously subjected to XPac analysis.

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Published date: 2012
Organisations: Organic Chemistry: Synthesis, Catalysis and Flow, Chemistry, Faculty of Natural and Environmental Sciences

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Local EPrints ID: 347410
URI: http://eprints.soton.ac.uk/id/eprint/347410
ISSN: 1466-8033
PURE UUID: 5d95df61-a1b4-447b-a18f-d3ec6042fd9f

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Date deposited: 28 Jan 2013 14:17
Last modified: 16 Jul 2019 21:45

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