Burdett, Edward, Dushianthan, Ahilanandan, Bennett-Guerrero, Elliott, Cro, Suzie, Gan, Tong J., Grocott, Michael P.W., James, Michael F.M., Mythen, Michael G., O'Malley, Catherine M.N., Roche, Anthony M. and Rowan, Kathy
Perioperative buffered versus non-buffered fluid administration for surgery in adults
Cochrane Database of Systematic Reviews, 12, . (doi:10.1002/14651858.CD004089.pub2). (PMID:23235602).
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The administration of buffered fluids to adult patients during surgery is equally safe and effective as the administration of non-buffered saline-based fluids. The use of buffered fluids is associated with less metabolic derangement, in particular hyperchloraemia and metabolic acidosis. Larger studies are needed to assess robust outcomes such as mortality.
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