The University of Southampton
University of Southampton Institutional Repository

Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery

Grocott, Michael P.W., Dushianthan, Ahilanandan, Hamilton, Mark A., Mythen, Michael G., Harrison, David and Rowan, Kathy (2012) Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery Cochrane Database of Systematic Reviews, 11, CD004082. (doi:10.1002/14651858.CD004082.pub5). (PMID:23152223).

Record type: Article


It remains uncertain whether increasing blood flow using fluids, with or without inotropes or vasoactive drugs, reduces mortality in adults undergoing surgery. The primary analysis in this review (mortality at longest follow-up) showed no difference between the intervention and control, but this result was sensitive to the method of analysis, the withdrawal of studies with methodological limitations, and is dominated by a single large RCT. Overall, for every 100 patients in whom blood flow is increased perioperatively to defined goals, one can expect 13 in 100 patients (from 40/100 to 27/100) to avoid a complication, 2/100 to avoid renal impairment (from 8/100 to 6/100), 5/100 to avoid respiratory failure (from 10/100 to 5/100), and 4/100 to avoid postoperative wound infection (from 10/100 to 6/100). On average, patients receiving the intervention stay in hospital one day less. It is unlikely that the intervention causes harm. The balance of current evidence does not support widespread implementation of this approach to reduce mortality but does suggest that complications and duration of hospital stay are reduced.

Full text not available from this repository.

More information

Published date: 14 November 2012


Local EPrints ID: 347545
ISSN: 1469-493X
PURE UUID: 644a8396-8a36-47bd-b1cf-fffff1a21c83

Catalogue record

Date deposited: 24 Jan 2013 09:52
Last modified: 18 Jul 2017 04:57

Export record



Author: Ahilanandan Dushianthan
Author: Mark A. Hamilton
Author: Michael G. Mythen
Author: David Harrison
Author: Kathy Rowan

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.