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Surface transport and stable trapping of particles and cells by an optical waveguide loop

Surface transport and stable trapping of particles and cells by an optical waveguide loop
Surface transport and stable trapping of particles and cells by an optical waveguide loop
Waveguide trapping has emerged as a useful technique for parallel and planar transport of particles and biological cells and can be integrated with lab-on-a-chip applications. However, particles trapped on waveguides are continuously propelled forward along the surface of the waveguide. This limits the practical usability of the waveguide trapping technique with other functions (e.g. analysis, imaging) that require particles to be stationary during diagnosis. In this paper, an optical waveguide loop with an intentional gap at the centre is proposed to hold propelled particles and cells. The waveguide acts as a conveyor belt to transport and deliver the particles/cells towards the gap. At the gap, the diverging light fields hold the particles at a fixed position. The proposed waveguide design is numerically studied and experimentally implemented. The optical forces on the particle at the gap are calculated using the finite element method. Experimentally, the method is used to transport and trap micro-particles and red blood cells at the gap with varying separations. The waveguides are only 180 nm thick and thus could be integrated with other functions on the chip, e.g. microfluidics or optical detection, to make an on-chip system for single cell analysis and to study the interaction between cells.
1473-0197
3436-3440
Hellesø, Olav Gaute
7c341b6b-c11d-475d-aedd-558f02210e53
Løvhaugen, Pål
65b8387f-ca56-4c9f-b661-dc7b96cb577a
Subramanian, Ananth Z.
051aee73-cf97-4738-8784-fbaff72bd6b9
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0
Hellesø, Olav Gaute
7c341b6b-c11d-475d-aedd-558f02210e53
Løvhaugen, Pål
65b8387f-ca56-4c9f-b661-dc7b96cb577a
Subramanian, Ananth Z.
051aee73-cf97-4738-8784-fbaff72bd6b9
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0

Hellesø, Olav Gaute, Løvhaugen, Pål, Subramanian, Ananth Z., Wilkinson, James S. and Ahluwalia, Balpreet Singh (2012) Surface transport and stable trapping of particles and cells by an optical waveguide loop. Lab on a Chip, 12 (18), 3436-3440. (doi:10.1039/c2lc40375g).

Record type: Article

Abstract

Waveguide trapping has emerged as a useful technique for parallel and planar transport of particles and biological cells and can be integrated with lab-on-a-chip applications. However, particles trapped on waveguides are continuously propelled forward along the surface of the waveguide. This limits the practical usability of the waveguide trapping technique with other functions (e.g. analysis, imaging) that require particles to be stationary during diagnosis. In this paper, an optical waveguide loop with an intentional gap at the centre is proposed to hold propelled particles and cells. The waveguide acts as a conveyor belt to transport and deliver the particles/cells towards the gap. At the gap, the diverging light fields hold the particles at a fixed position. The proposed waveguide design is numerically studied and experimentally implemented. The optical forces on the particle at the gap are calculated using the finite element method. Experimentally, the method is used to transport and trap micro-particles and red blood cells at the gap with varying separations. The waveguides are only 180 nm thick and thus could be integrated with other functions on the chip, e.g. microfluidics or optical detection, to make an on-chip system for single cell analysis and to study the interaction between cells.

Full text not available from this repository.

More information

Published date: 21 June 2012
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 347660
URI: http://eprints.soton.ac.uk/id/eprint/347660
ISSN: 1473-0197
PURE UUID: 2187478f-1ccd-42dd-b4bd-64dc7b7fb867
ORCID for James S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697

Catalogue record

Date deposited: 29 Jan 2013 11:24
Last modified: 18 Feb 2021 16:32

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