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Highly enantioselective cascade synthesis of spiropyrazolones

Highly enantioselective cascade synthesis of spiropyrazolones
Highly enantioselective cascade synthesis of spiropyrazolones
An efficient synthesis of spiropyrazolones based on organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo- and enantioselectivities.
1477-0520
6519-6523
Zea, Alex
e1cc8e2a-e3f2-46a2-8463-3015712bdb96
Alba, Andrea-Nekane R.
d1750aca-a087-449c-8466-11fb54264bea
Mazzanti, Andrea
1e31a7a1-e163-4bd4-9e72-42bc64f60277
Moyano, Albert
07f92405-40f4-4fc4-97b3-9bd5c9c14baa
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Zea, Alex
e1cc8e2a-e3f2-46a2-8463-3015712bdb96
Alba, Andrea-Nekane R.
d1750aca-a087-449c-8466-11fb54264bea
Mazzanti, Andrea
1e31a7a1-e163-4bd4-9e72-42bc64f60277
Moyano, Albert
07f92405-40f4-4fc4-97b3-9bd5c9c14baa
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441

Zea, Alex, Alba, Andrea-Nekane R., Mazzanti, Andrea, Moyano, Albert and Rios, Ramon (2011) Highly enantioselective cascade synthesis of spiropyrazolones. Organic & Biomolecular Chemistry, 9 (19), 6519-6523. (doi:10.1039/C1OB05753G). (PMID:21842077)

Record type: Article

Abstract

An efficient synthesis of spiropyrazolones based on organocatalysis is described. The reaction between pyrazolones, enolizable aldehydes and enals is catalyzed by secondary amine catalysts and affords the final spiro compounds bearing four contiguous chiral centers in good yields and excellent diastereo- and enantioselectivities.

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More information

e-pub ahead of print date: 10 June 2011
Published date: 2011
Organisations: Chemistry
Learn more about Chemistry research

Identifiers

Local EPrints ID: 347688
URI: http://eprints.soton.ac.uk/id/eprint/347688
DOI: doi:10.1039/C1OB05753G
ISSN: 1477-0520
PURE UUID: d6125802-74b3-49af-b70b-cfcd53603ec5
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 29 Jan 2013 10:22
Last modified: 14 Mar 2024 12:51

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Contributors

Author: Alex Zea
Author: Andrea-Nekane R. Alba
Author: Andrea Mazzanti
Author: Albert Moyano
Author: Ramon Rios ORCID iD

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