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Enantioselective organocatalytic synthesis of fluorinated molecules

Enantioselective organocatalytic synthesis of fluorinated molecules
Enantioselective organocatalytic synthesis of fluorinated molecules
The enantioselective synthesis of fluorinated molecules has drawn much attention within the chemical community due to its unique stereoelectronic properties. The main aim of this review is to cover the most important organocatalytic enantioselective methodologies to obtain them. The review is divided into three parts: first, the direct introduction of a fluorine atom studied in the early 2000s. Second, the later use of Michael reactions to introduce fluorine-containing synthons. Finally, the simultaneously-developed trifluoromethylation reactions, giving the catalysts, mechanisms and reagents that have been used.
enamines, fluorine, michael reaction, organocatalysis, trifluoromethylation
0947-6539
2018-2037
Valero, Guillem
c5f692fe-3b07-4916-a4ec-23f78a45cc15
Companyó, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Valero, Guillem
c5f692fe-3b07-4916-a4ec-23f78a45cc15
Companyó, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441

Valero, Guillem, Companyó, Xavier and Rios, Ramon (2011) Enantioselective organocatalytic synthesis of fluorinated molecules. Chemistry - A European Journal, 17 (7), 2018-2037. (doi:10.1002/chem.201001546). (PMID:21294172)

Record type: Article

Abstract

The enantioselective synthesis of fluorinated molecules has drawn much attention within the chemical community due to its unique stereoelectronic properties. The main aim of this review is to cover the most important organocatalytic enantioselective methodologies to obtain them. The review is divided into three parts: first, the direct introduction of a fluorine atom studied in the early 2000s. Second, the later use of Michael reactions to introduce fluorine-containing synthons. Finally, the simultaneously-developed trifluoromethylation reactions, giving the catalysts, mechanisms and reagents that have been used.

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More information

e-pub ahead of print date: 17 January 2011
Published date: 11 February 2011
Keywords: enamines, fluorine, michael reaction, organocatalysis, trifluoromethylation
Organisations: Chemistry

Identifiers

Local EPrints ID: 347697
URI: http://eprints.soton.ac.uk/id/eprint/347697
ISSN: 0947-6539
PURE UUID: 443922e5-4e34-406b-b6d1-f7f0bdb64cc2
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 29 Jan 2013 11:19
Last modified: 17 Dec 2019 01:38

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