Improving asymmetric organocatalysts via supramolecular interactions
Improving asymmetric organocatalysts via supramolecular interactions
Since the rediscovery of proline as a catalyst in aldol reaction in 2000 by List, Barbas and Lerner and, soon after, the development of imonium catalysis by D. W. C. MacMillan, the emergence of Organocatalysis as an important instrument in Organic Synthesis is outstanding. Nowadays, one of the most important goals for chemist is the quest for new and more efficient catalysts. One emerging tool for improving existent organocatalysts consists in using additives which interact with the catalysts via supramolecular interactions such as hydrogen bonding. These interactions provide better catalysts in terms of activity and selectivity. The present review aims to cover and discuss the current evolution of this fast growing field.
organocatalysis, hydrogen bond, supramolecular interactions, enantioselective catalysis
1-9
Companyo, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Viciano, Monica
57a5b8e6-9de2-4140-b5b6-e3d08d274129
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
2010
Companyo, Xavier
446791db-6e0a-40f9-9f20-3a8e8af9803c
Viciano, Monica
57a5b8e6-9de2-4140-b5b6-e3d08d274129
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Companyo, Xavier, Viciano, Monica and Rios, Ramon
(2010)
Improving asymmetric organocatalysts via supramolecular interactions.
Mini-Reviews in Organic Chemistry, 7 (1), .
Abstract
Since the rediscovery of proline as a catalyst in aldol reaction in 2000 by List, Barbas and Lerner and, soon after, the development of imonium catalysis by D. W. C. MacMillan, the emergence of Organocatalysis as an important instrument in Organic Synthesis is outstanding. Nowadays, one of the most important goals for chemist is the quest for new and more efficient catalysts. One emerging tool for improving existent organocatalysts consists in using additives which interact with the catalysts via supramolecular interactions such as hydrogen bonding. These interactions provide better catalysts in terms of activity and selectivity. The present review aims to cover and discuss the current evolution of this fast growing field.
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Published date: 2010
Keywords:
organocatalysis, hydrogen bond, supramolecular interactions, enantioselective catalysis
Organisations:
Chemistry
Identifiers
Local EPrints ID: 347715
URI: http://eprints.soton.ac.uk/id/eprint/347715
ISSN: 1570-193X
PURE UUID: 73689c99-ef28-4081-a19b-617f8aa11bc3
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Date deposited: 29 Jan 2013 12:14
Last modified: 09 Jan 2022 03:40
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Contributors
Author:
Xavier Companyo
Author:
Monica Viciano
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