A mild and convenient synthesis of 4-tosyl-4,5-dihydrooxazoles

Companyo, Xavier, Moyano, Albert and Rios, Ramon (2009) A mild and convenient synthesis of 4-tosyl-4,5-dihydrooxazoles. Letters in Organic Chemistry, 6 (4), 293-296.

Record type: Article

Abstract

A facile and mild synthesis of 4-tosyl-4,5-dihydrooxazoles is described. The reaction between tosyl methyl isocyanide (TosMIC) and cinnamic or aromatic aldehydes is catalyzed by triethylamine, affording trans-5-styryl- or 5-aryl-4- tosyl-4,5-dihydrooxazoles in quantitative yields without further purification. The mild reaction conditions allowed for the first time the use of cinnamaldehyde derivatives with excellent results.

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Published date: 1 June 2009

Keywords: TosMIC, catalytic reaction, ?, ?-unsaturated aldehydes, oxazolines, 4, 5-dihydrooxazoles

Organisations: Chemistry

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Identifiers

Local EPrints ID: 347723

URI: http://eprints.soton.ac.uk/id/eprint/347723

ISSN: 1570-1786

PURE UUID: 5d0656c8-b66d-480b-8374-5e72d1326ce3

ORCID for Ramon Rios:

orcid.org/0000-0002-3843-8521

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Date deposited: 29 Jan 2013 13:01

Last modified: 09 Jan 2022 03:40

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Contributors

Author: Xavier Companyo

Author: Albert Moyano

Author: Ramon Rios

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