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Arousal-state modulation in children with AD/HD

Arousal-state modulation in children with AD/HD
Arousal-state modulation in children with AD/HD
Objective: To investigate the effect of arousal-state modulation, via manipulation of stimulus event-rate,
on response inhibition in children with Attention-Deficit/Hyperactivity disorder (AD/HD) using behavioural
and ERP measures.
Methods: Eighteen children with AD/HD, aged 7–14 years, and 18 age-and sex-matched controls performed
a cued visual Go/Nogo task (70% Go) with stimuli presented at fast, medium and slow event-rates.
Task performance and ERPs to Warning, Go and Nogo stimuli, as well as preparation between the S1–S2
interval, were examined for group differences.
Results: AD/HD subjects displayed poorer response inhibition during the fast condition, accompanied by
a reduced Nogo P3. Group differences during the fast rate extended to Warning cues, with the AD/HD
group showing ERP evidence of atypical orienting/preparation, as indexed by the early and late CNV,
and early sensory/attentive processing prior to S2.
Conclusions: Although deficient response inhibition has been proposed as the core deficit in AD/HD, the
results of the present study highlight the key role of energetic factors. Furthermore, group differences
found to cues suggest that this effect extends to the processing of task-irrelevant stimuli.
Significance: This was the first ERP Go/Nogo task investigation using three event-rates, and the results
support the theory that state factors may contribute to response inhibition deficits in AD/HD.
30-40
Benikos, Nicholas P.
4db1d756-1626-4634-b8f2-1cc60079f808
Johnstone, Stuart J.
0a0ca113-3204-4fd3-b9bb-26a0ec0b65f0
Benikos, Nicholas P.
4db1d756-1626-4634-b8f2-1cc60079f808
Johnstone, Stuart J.
0a0ca113-3204-4fd3-b9bb-26a0ec0b65f0

Benikos, Nicholas P. and Johnstone, Stuart J. (2009) Arousal-state modulation in children with AD/HD. Clinical Neurophysiology, 120 (1), 30-40. (doi:10.1016/j.clinph.2008.09.026). (PMID:19027356)

Record type: Article

Abstract

Objective: To investigate the effect of arousal-state modulation, via manipulation of stimulus event-rate,
on response inhibition in children with Attention-Deficit/Hyperactivity disorder (AD/HD) using behavioural
and ERP measures.
Methods: Eighteen children with AD/HD, aged 7–14 years, and 18 age-and sex-matched controls performed
a cued visual Go/Nogo task (70% Go) with stimuli presented at fast, medium and slow event-rates.
Task performance and ERPs to Warning, Go and Nogo stimuli, as well as preparation between the S1–S2
interval, were examined for group differences.
Results: AD/HD subjects displayed poorer response inhibition during the fast condition, accompanied by
a reduced Nogo P3. Group differences during the fast rate extended to Warning cues, with the AD/HD
group showing ERP evidence of atypical orienting/preparation, as indexed by the early and late CNV,
and early sensory/attentive processing prior to S2.
Conclusions: Although deficient response inhibition has been proposed as the core deficit in AD/HD, the
results of the present study highlight the key role of energetic factors. Furthermore, group differences
found to cues suggest that this effect extends to the processing of task-irrelevant stimuli.
Significance: This was the first ERP Go/Nogo task investigation using three event-rates, and the results
support the theory that state factors may contribute to response inhibition deficits in AD/HD.

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More information

Published date: January 2009
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 347857
URI: https://eprints.soton.ac.uk/id/eprint/347857
PURE UUID: dc25e6f8-b0e7-42e6-a668-0ba2e1d2312f

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Date deposited: 05 Feb 2013 10:06
Last modified: 18 Jul 2017 04:55

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Contributors

Author: Nicholas P. Benikos
Author: Stuart J. Johnstone

University divisions

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