Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammation
Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammation
Pre-eclampsia (PE) is a multi-system disorder of human pregnancy, characterised by hypertension and proteinuria. Although the pathogenesis of PE is not fully understood, predisposition to endothelial dysfunction is thought to play a crucial part. Despite intensive research there is no reliable test for screening purposes or to inform decision making towards effective treatment for PE. Understanding the link between PE, abnormal haemostatic activation and inflammation may help to elucidate some of the patho-physiology of the disease; primary preventative measures and targeted therapies at an early stage of the disease could then be considered. In the present paper we discuss potential causal links between PE, haemostasis and inflammation. The potential implications of such interaction on the pathogenesis of PE are also addressed.
pre-eclampsia, coagulation, fibrinolysis, inflammation, microparticles
17-21
Dusse, Luci M.
fd43ba62-4bfe-4503-b0ae-2593b0c66b0f
Rios, Danyelle R.A.
5d6823cc-ce1e-4ab0-84f6-e9b4a69145f3
Pinheiro, Melina B.
b40c976a-297a-49d0-b67d-91f260c762c6
Cooper, Alan J.
65dcd1e1-3fcd-46b8-ad5f-f17e0d5b80a5
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
2011
Dusse, Luci M.
fd43ba62-4bfe-4503-b0ae-2593b0c66b0f
Rios, Danyelle R.A.
5d6823cc-ce1e-4ab0-84f6-e9b4a69145f3
Pinheiro, Melina B.
b40c976a-297a-49d0-b67d-91f260c762c6
Cooper, Alan J.
65dcd1e1-3fcd-46b8-ad5f-f17e0d5b80a5
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Dusse, Luci M., Rios, Danyelle R.A., Pinheiro, Melina B., Cooper, Alan J. and Lwaleed, Bashir A.
(2011)
Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammation.
Clinica Chimica Acta, 412 (1-2), .
(doi:10.1016/j.cca.2010.09.030).
(PMID:20888809)
Abstract
Pre-eclampsia (PE) is a multi-system disorder of human pregnancy, characterised by hypertension and proteinuria. Although the pathogenesis of PE is not fully understood, predisposition to endothelial dysfunction is thought to play a crucial part. Despite intensive research there is no reliable test for screening purposes or to inform decision making towards effective treatment for PE. Understanding the link between PE, abnormal haemostatic activation and inflammation may help to elucidate some of the patho-physiology of the disease; primary preventative measures and targeted therapies at an early stage of the disease could then be considered. In the present paper we discuss potential causal links between PE, haemostasis and inflammation. The potential implications of such interaction on the pathogenesis of PE are also addressed.
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Published date: 2011
Keywords:
pre-eclampsia, coagulation, fibrinolysis, inflammation, microparticles
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 347862
URI: http://eprints.soton.ac.uk/id/eprint/347862
ISSN: 0009-8981
PURE UUID: 62991245-051f-440f-88fe-7354a2774a04
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Date deposited: 31 Jan 2013 14:41
Last modified: 06 Aug 2024 01:39
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Contributors
Author:
Luci M. Dusse
Author:
Danyelle R.A. Rios
Author:
Melina B. Pinheiro
Author:
Alan J. Cooper
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