The University of Southampton
University of Southampton Institutional Repository

Treatment failure in osteoporosis

Treatment failure in osteoporosis
Treatment failure in osteoporosis
Summary: guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided.

Introduction: this study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture.

Methods: a working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making.

Results: in the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by anti-resorptive therapy and where bone mineral density continues to decrease.

Conclusion: the provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue
0937-941X
2769-2774
Diez-Perez, A.
19f89c53-003a-469c-92ac-69b0b979f3ec
Adachi, J.D
0a13a8a2-6cf0-4a0d-828f-d98140151642
Agnusdei, D.
87e480e3-4d99-404a-afc2-51e44b74ba00
Bilezikian, J.P.
956b4a04-b893-43ef-b8b9-8637c51c1bcf
Compston, J.E.
9ca6284a-7cfc-4674-bd0a-7ff4b323a910
Cummings, S.R.
884b6fba-5ac1-43d3-8eeb-42a29e3218c3
Eastell, R.
1650872d-d27d-4543-a112-d6008810fa25
Eriksen, E.F.
be8211e6-866a-4939-95a9-31d237fdaac6
Gonzalez-Macias, J.
1c441f12-35fd-412c-bd7d-60795954864c
Liberman, U.A.
b8938f4b-bd2b-464c-a074-053d8fa77c7b
Wahl, D.A.
32cf9afd-a852-4818-aad2-e6fb29443059
Seeman, E.
bda77f60-3ab2-4a4c-9429-8b6d5f55be96
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
IOF CSA Inadequate Responders Working Group
Diez-Perez, A.
19f89c53-003a-469c-92ac-69b0b979f3ec
Adachi, J.D
0a13a8a2-6cf0-4a0d-828f-d98140151642
Agnusdei, D.
87e480e3-4d99-404a-afc2-51e44b74ba00
Bilezikian, J.P.
956b4a04-b893-43ef-b8b9-8637c51c1bcf
Compston, J.E.
9ca6284a-7cfc-4674-bd0a-7ff4b323a910
Cummings, S.R.
884b6fba-5ac1-43d3-8eeb-42a29e3218c3
Eastell, R.
1650872d-d27d-4543-a112-d6008810fa25
Eriksen, E.F.
be8211e6-866a-4939-95a9-31d237fdaac6
Gonzalez-Macias, J.
1c441f12-35fd-412c-bd7d-60795954864c
Liberman, U.A.
b8938f4b-bd2b-464c-a074-053d8fa77c7b
Wahl, D.A.
32cf9afd-a852-4818-aad2-e6fb29443059
Seeman, E.
bda77f60-3ab2-4a4c-9429-8b6d5f55be96
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Diez-Perez, A., Adachi, J.D, Agnusdei, D., Bilezikian, J.P., Compston, J.E., Cummings, S.R., Eastell, R., Eriksen, E.F., Gonzalez-Macias, J., Liberman, U.A., Wahl, D.A., Seeman, E., Kanis, J.A. and Cooper, C. , IOF CSA Inadequate Responders Working Group (2012) Treatment failure in osteoporosis. Osteoporosis International, 23 (12), 2769-2774. (doi:10.1007/s00198-012-2093-8). (PMID:22836278)

Record type: Article

Abstract

Summary: guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided.

Introduction: this study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture.

Methods: a working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making.

Results: in the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by anti-resorptive therapy and where bone mineral density continues to decrease.

Conclusion: the provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue

Full text not available from this repository.

More information

Published date: December 2012
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 347873
URI: http://eprints.soton.ac.uk/id/eprint/347873
ISSN: 0937-941X
PURE UUID: 95563141-37f3-4656-a3ea-6fcc64f1a669
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 01 Feb 2013 11:31
Last modified: 17 Dec 2019 01:56

Export record

Altmetrics

Contributors

Author: A. Diez-Perez
Author: J.D Adachi
Author: D. Agnusdei
Author: J.P. Bilezikian
Author: J.E. Compston
Author: S.R. Cummings
Author: R. Eastell
Author: E.F. Eriksen
Author: J. Gonzalez-Macias
Author: U.A. Liberman
Author: D.A. Wahl
Author: E. Seeman
Author: J.A. Kanis
Author: C. Cooper ORCID iD
Corporate Author: IOF CSA Inadequate Responders Working Group

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×