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Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to beta-amino acids

Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to beta-amino acids
Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to beta-amino acids
The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and alpha,beta-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and beta-amino acids in high yields and with 90-99% ee.
1359-7345
849-851
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Zhao, Gui-Ling
106737c0-2aeb-4805-a8d7-496b1ce04322
Cordova, Armando
2faa4bb2-1830-4176-93c6-2218854573d4
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Zhao, Gui-Ling
106737c0-2aeb-4805-a8d7-496b1ce04322
Cordova, Armando
2faa4bb2-1830-4176-93c6-2218854573d4

Ibrahem, Ismail, Rios, Ramon, Vesely, Jan, Zhao, Gui-Ling and Cordova, Armando (2007) Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to beta-amino acids. Chemical Communications, (8), 849-851. (doi:10.1039/B613410F). (PMID:17308652)

Record type: Article

Abstract

The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and alpha,beta-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and beta-amino acids in high yields and with 90-99% ee.

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More information

e-pub ahead of print date: 14 September 2006
Published date: 2007
Organisations: Chemistry
Learn more about Chemistry research

Identifiers

Local EPrints ID: 347973
URI: http://eprints.soton.ac.uk/id/eprint/347973
DOI: doi:10.1039/B613410F
ISSN: 1359-7345
PURE UUID: 08b43a88-3cb1-47f1-a7c7-d48d79795155
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 05 Feb 2013 09:42
Last modified: 14 Mar 2024 12:54

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Contributors

Author: Ismail Ibrahem
Author: Ramon Rios ORCID iD
Author: Jan Vesely
Author: Gui-Ling Zhao
Author: Armando Cordova

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