Enantioselective organocatalytic conjugate addition of amines to ?,?-unsaturated aldehydes: one-pot asymmetric synthesis of ?-amino acids and 1,3-diamines
Enantioselective organocatalytic conjugate addition of amines to ?,?-unsaturated aldehydes: one-pot asymmetric synthesis of ?-amino acids and 1,3-diamines
Organocatalytic asymmetric amine conjugate additions to ?,?-unsaturated aldehydes catalyzed by protected diarylprolinols are presented. The reactions proceed with high enantioselectivity and result in Cbz or Boc protected ?-amino aldehydes, ?-amino alcohols, ?-amino acids and 1,3-diamines with typically 82–99% ee.
2193-2198
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Zhao, Gui-Ling
106737c0-2aeb-4805-a8d7-496b1ce04322
Xu, Yongmei
77a1cd82-b3af-4fab-bb76-23523d8224a0
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac
19 March 2007
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Zhao, Gui-Ling
106737c0-2aeb-4805-a8d7-496b1ce04322
Xu, Yongmei
77a1cd82-b3af-4fab-bb76-23523d8224a0
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac
Vesely, Jan, Ibrahem, Ismail, Rios, Ramon, Zhao, Gui-Ling, Xu, Yongmei and Córdova, Armando
(2007)
Enantioselective organocatalytic conjugate addition of amines to ?,?-unsaturated aldehydes: one-pot asymmetric synthesis of ?-amino acids and 1,3-diamines.
Tetrahedron Letters, 48 (12), .
(doi:10.1016/j.tetlet.2007.01.093).
Abstract
Organocatalytic asymmetric amine conjugate additions to ?,?-unsaturated aldehydes catalyzed by protected diarylprolinols are presented. The reactions proceed with high enantioselectivity and result in Cbz or Boc protected ?-amino aldehydes, ?-amino alcohols, ?-amino acids and 1,3-diamines with typically 82–99% ee.
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Published date: 19 March 2007
Organisations:
Chemistry
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Local EPrints ID: 347978
URI: http://eprints.soton.ac.uk/id/eprint/347978
ISSN: 0040-4039
PURE UUID: d9dd624d-be23-4ff5-b257-4af5a25dd253
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Date deposited: 05 Feb 2013 09:59
Last modified: 14 Mar 2024 12:54
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Contributors
Author:
Jan Vesely
Author:
Ismail Ibrahem
Author:
Gui-Ling Zhao
Author:
Yongmei Xu
Author:
Armando Córdova
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