Enantioselective organocatalytic hydrophosphination of ?,?-unsaturated aldehydes
Enantioselective organocatalytic hydrophosphination of ?,?-unsaturated aldehydes
Optically active phosphine derivatives can be obtained in high yields and in up to 99?%?ee by using simple chiral amines to catalyze the hydrophosphination of ?,?-unsaturated aldehydes (see scheme, green sphere=chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of ?-phosphine oxide acids.
aldehydes, asymmetric synthesis, conjugate addition, organocatalysis, phosphanes
4507-4510
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Hammar, Peter
b82887fb-0424-4890-940a-2c87eefb1a0e
Eriksson, Lars
340ffb17-9c8e-468f-acba-13219dc22c37
Himo, Fahmi
dbde3654-3b13-412e-838e-70d49cc83d36
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac
11 June 2007
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Hammar, Peter
b82887fb-0424-4890-940a-2c87eefb1a0e
Eriksson, Lars
340ffb17-9c8e-468f-acba-13219dc22c37
Himo, Fahmi
dbde3654-3b13-412e-838e-70d49cc83d36
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac
Ibrahem, Ismail, Rios, Ramon, Vesely, Jan, Hammar, Peter, Eriksson, Lars, Himo, Fahmi and Córdova, Armando
(2007)
Enantioselective organocatalytic hydrophosphination of ?,?-unsaturated aldehydes.
Angewandte Chemie International Edition, 46 (24), .
(doi:10.1002/anie.200700916).
(PMID:17492816)
Abstract
Optically active phosphine derivatives can be obtained in high yields and in up to 99?%?ee by using simple chiral amines to catalyze the hydrophosphination of ?,?-unsaturated aldehydes (see scheme, green sphere=chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of ?-phosphine oxide acids.
This record has no associated files available for download.
More information
Published date: 11 June 2007
Keywords:
aldehydes, asymmetric synthesis, conjugate addition, organocatalysis, phosphanes
Organisations:
Chemistry
Identifiers
Local EPrints ID: 347982
URI: http://eprints.soton.ac.uk/id/eprint/347982
ISSN: 1433-7851
PURE UUID: 1e67b096-5ba1-4328-8c89-78fc994adab6
Catalogue record
Date deposited: 05 Feb 2013 10:11
Last modified: 14 Mar 2024 12:54
Export record
Altmetrics
Contributors
Author:
Ismail Ibrahem
Author:
Jan Vesely
Author:
Peter Hammar
Author:
Lars Eriksson
Author:
Fahmi Himo
Author:
Armando Córdova
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
