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A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis

A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis
A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis
The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and ?,?-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91–99% ee.
0040-4039
5701-5705
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Zhao, Gui-Ling
106737c0-2aeb-4805-a8d7-496b1ce04322
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Zhao, Gui-Ling
106737c0-2aeb-4805-a8d7-496b1ce04322
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac

Rios, Ramon, Ibrahem, Ismail, Vesely, Jan, Zhao, Gui-Ling and Córdova, Armando (2007) A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis. Tetrahedron Letters, 48 (32), 5701-5705. (doi:10.1016/j.tetlet.2007.05.176).

Record type: Article

Abstract

The highly chemo- and enantioselective organocatalytic three-component reaction between N-arylhydroxylamines, aldehydes and ?,?-unsaturated aldehydes is presented; the reaction gives access to isoxazolidines in high yields with >25:1 dr and 91–99% ee.

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More information

Published date: 6 August 2007
Organisations: Chemistry
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Identifiers

Local EPrints ID: 347984
URI: http://eprints.soton.ac.uk/id/eprint/347984
DOI: doi:10.1016/j.tetlet.2007.05.176
ISSN: 0040-4039
PURE UUID: 29ba6a24-3437-4253-a3dc-e96cf059440a
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

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Date deposited: 05 Feb 2013 10:15
Last modified: 14 Mar 2024 12:54

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Contributors

Author: Ramon Rios ORCID iD
Author: Ismail Ibrahem
Author: Jan Vesely
Author: Gui-Ling Zhao
Author: Armando Córdova

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