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Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives

Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives
Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives
The highly chemo- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2-aminomalonates and ?,?-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with >10:1 dr and 90–98% ee.
0040-4039
6252-6257
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac
Ibrahem, Ismail
3cbac9c1-431b-4a1f-8c41-92aa617254b0
Rios, Ramon
609bedf2-e886-4d62-a676-a32b6f8c1441
Vesely, Jan
1853ff19-a906-4321-bd69-f7e434176fc3
Córdova, Armando
d2a1239f-708d-4f9c-bf7c-c095e9a27cac

Ibrahem, Ismail, Rios, Ramon, Vesely, Jan and Córdova, Armando (2007) Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives. Tetrahedron Letters, 48 (36), 6252-6257. (doi:10.1016/j.tetlet.2007.07.031).

Record type: Article

Abstract

The highly chemo- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2-aminomalonates and ?,?-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with >10:1 dr and 90–98% ee.

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Published date: 3 September 2007
Organisations: Chemistry
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Identifiers

Local EPrints ID: 347987
URI: http://eprints.soton.ac.uk/id/eprint/347987
DOI: doi:10.1016/j.tetlet.2007.07.031
ISSN: 0040-4039
PURE UUID: 8c8b5c28-a1e0-4817-a48e-07e8e0029bc3
ORCID for Ramon Rios: ORCID iD orcid.org/0000-0002-3843-8521

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Date deposited: 05 Feb 2013 10:23
Last modified: 14 Mar 2024 12:54

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Contributors

Author: Ismail Ibrahem
Author: Ramon Rios ORCID iD
Author: Jan Vesely
Author: Armando Córdova

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