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Examples of catalytic asymmetric amine synthesis using organic catalysts

Examples of catalytic asymmetric amine synthesis using organic catalysts
Examples of catalytic asymmetric amine synthesis using organic catalysts
The asymmetric construction of optically active amine compounds is of paramount interest for the chemical industry and academic research. This review describes the use of catalytic asymmetric transformations, such as Mannich-type, Michael, cycloaddition and transfer-hydrogenation reactions using small organic molecules (eg, amino acids, secondary amines, peptides, thioureas and phosphoric acids) as catalysts, for the construction of important compounds for medicinal chemistry that exhibit anticancer, antibiotic or antiviral activity.
1367-6733
824-847
Rios, R.
609bedf2-e886-4d62-a676-a32b6f8c1441
Córdova, A.
8e10913c-2f20-4fa3-99dd-73c0c51a16e8
Rios, R.
609bedf2-e886-4d62-a676-a32b6f8c1441
Córdova, A.
8e10913c-2f20-4fa3-99dd-73c0c51a16e8

Rios, R. and Córdova, A. (2009) Examples of catalytic asymmetric amine synthesis using organic catalysts. Current Opinion in Drug Discovery & Development, 12 (6), 824-847. (PMID:19894193)

Record type: Article

Abstract

The asymmetric construction of optically active amine compounds is of paramount interest for the chemical industry and academic research. This review describes the use of catalytic asymmetric transformations, such as Mannich-type, Michael, cycloaddition and transfer-hydrogenation reactions using small organic molecules (eg, amino acids, secondary amines, peptides, thioureas and phosphoric acids) as catalysts, for the construction of important compounds for medicinal chemistry that exhibit anticancer, antibiotic or antiviral activity.

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Published date: November 2009
Organisations: Chemistry

Identifiers

Local EPrints ID: 348007
URI: http://eprints.soton.ac.uk/id/eprint/348007
ISSN: 1367-6733
PURE UUID: 8cd16fe9-45d3-429f-bbb4-e337d18daf67
ORCID for R. Rios: ORCID iD orcid.org/0000-0002-3843-8521

Catalogue record

Date deposited: 05 Feb 2013 11:48
Last modified: 20 Jul 2019 00:42

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