Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor
receptor signalling
Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor
receptor signalling
A pinched-flow deflection technology was developed for rapid
single cell switching between biochemical microenvironments.
Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling.
1031-1034
Chiang, Ya-Yu
0ab4fe9e-9a3e-4594-a13c-73f68c13b8b3
West, Jonathan
f1c2e060-16c3-44c0-af70-242a1c58b968
21 March 2013
Chiang, Ya-Yu
0ab4fe9e-9a3e-4594-a13c-73f68c13b8b3
West, Jonathan
f1c2e060-16c3-44c0-af70-242a1c58b968
Chiang, Ya-Yu and West, Jonathan
(2013)
Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor
receptor signalling.
Lab on a Chip, 13 (6), .
(doi:10.1039/C3LC41297K).
Abstract
A pinched-flow deflection technology was developed for rapid
single cell switching between biochemical microenvironments.
Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling.
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Chiang_CellSwitch_LOC2013.pdf
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e-pub ahead of print date: 11 January 2013
Published date: 21 March 2013
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 348022
URI: http://eprints.soton.ac.uk/id/eprint/348022
ISSN: 1473-0197
PURE UUID: 2af26c49-3821-4f34-8304-b9c80e220994
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Date deposited: 05 Feb 2013 14:25
Last modified: 15 Mar 2024 03:43
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Author:
Ya-Yu Chiang
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