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Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling
Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling
A pinched-flow deflection technology was developed for rapid
single cell switching between biochemical microenvironments.
Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling.
1473-0197
1031-1034
Chiang, Ya-Yu
0ab4fe9e-9a3e-4594-a13c-73f68c13b8b3
West, Jonathan
f1c2e060-16c3-44c0-af70-242a1c58b968
Chiang, Ya-Yu
0ab4fe9e-9a3e-4594-a13c-73f68c13b8b3
West, Jonathan
f1c2e060-16c3-44c0-af70-242a1c58b968

Chiang, Ya-Yu and West, Jonathan (2013) Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling. Lab on a Chip, 13 (6), 1031-1034. (doi:10.1039/C3LC41297K).

Record type: Article

Abstract

A pinched-flow deflection technology was developed for rapid
single cell switching between biochemical microenvironments.
Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling.

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More information

e-pub ahead of print date: 11 January 2013
Published date: 21 March 2013
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 348022
URI: http://eprints.soton.ac.uk/id/eprint/348022
DOI: doi:10.1039/C3LC41297K
ISSN: 1473-0197
PURE UUID: 2af26c49-3821-4f34-8304-b9c80e220994
ORCID for Jonathan West: ORCID iD orcid.org/0000-0002-5709-6790

Catalogue record

Date deposited: 05 Feb 2013 14:25
Last modified: 15 Mar 2024 03:43

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Contributors

Author: Ya-Yu Chiang
Author: Jonathan West ORCID iD

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