Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

Liu, Xue Jun, Gingrich, Jeffrey R, Vargas-Caballero, Mariana, Dong, Yi Na, Sengar, Ameet, Beggs, Simon, Wang, Szu-Han, Ding, Hoi Ki, Frankland, Paul W and Salter, Michael W (2008) Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex. Nature Medicine, 14 (12), 1325-1332. (doi:10.1038/nm.1883). (PMID:19011637)

Abstract

Amyloid ? (A?) and tau protein are both implicated in memory impairment, mild cognitive impairment (MCI), and early Alzheimer's disease (AD), but whether and how they interact is unknown. Consequently, we asked whether tau protein is required for the robust phenomenon of A?-induced impairment of hippocampal long-term potentiation (LTP), a widely accepted cellular model of memory. We used wild-type mice and mice with a genetic knock-out of tau protein and recorded field potentials in an acute slice preparation. We demonstrate that the absence of tau protein prevents A?-induced impairment of LTP. Moreover, we show that A? increases tau phosphorylation and that a specific inhibitor of the tau kinase glycogen synthase kinase 3 blocks the increased tau phosphorylation induced by A? and prevents A?-induced impairment of LTP in wild-type mice. Together, these findings show that tau protein is required for A? to impair synaptic plasticity in the hippocampus and suggest that the A?-induced impairment of LTP is mediated by tau phosphorylation. We conclude that preventing the interaction between A? and tau could be a promising strategy for treating cognitive impairment in MCI and early AD.

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Contributors

Author: Mariana Vargas-Caballero

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