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Detection of cervical infections in colposcopy clinic patients

Detection of cervical infections in colposcopy clinic patients
Detection of cervical infections in colposcopy clinic patients
The purpose of this study was to determine if Neisseria gonorrhoeae; Chlamydia trachomatis; herpes simplex virus; cytomegalovirus; Epstein-Barr virus; human herpesviruses 6, 7, and 8; or adeno-associated virus influenced the production of cervical intraepithelial neoplasia. Two hundred thirty-one cervical smear samples were tested for the presence of the organisms by PCR. In addition, human papillomavirus types in the samples were determined by PCR and classified into cancer risk types of high, moderate, and low. There was no link with cervical intraepithelial neoplasia status and detection of herpes simplex virus, cytomegalovirus, Epstein-Barr virus, human herpesviruses 6 and 8, gonorrhea, or chlamydia. However, high-grade cervical intraepithelial neoplasia was found more frequently with mixed infection by moderate-risk human papillomavirus types and human herpesvirus 7 than with these papillomavirus types alone. The presence of human herpesvirus 7 may increase the oncogenic potential of moderate-risk human papillomavirus types.
0095-1137
2946-2950
Lanham, S.A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Herbert, A.
710f7d17-429a-433e-8802-b96d78e4dead
Basarab, A.
7eccfcf9-27ad-403f-984f-8c209b10eef1
Watt, P.J.
3ffa2cad-33c8-46bd-9aa1-74bfa9a37b4d
Lanham, S.A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Herbert, A.
710f7d17-429a-433e-8802-b96d78e4dead
Basarab, A.
7eccfcf9-27ad-403f-984f-8c209b10eef1
Watt, P.J.
3ffa2cad-33c8-46bd-9aa1-74bfa9a37b4d

Lanham, S.A., Herbert, A., Basarab, A. and Watt, P.J. (2001) Detection of cervical infections in colposcopy clinic patients. Journal of Clinical Microbiology, 39 (8), 2946-2950. (doi:10.1128/JCM.39.8.2946-2950.2001). (PMID:11474018)

Record type: Article

Abstract

The purpose of this study was to determine if Neisseria gonorrhoeae; Chlamydia trachomatis; herpes simplex virus; cytomegalovirus; Epstein-Barr virus; human herpesviruses 6, 7, and 8; or adeno-associated virus influenced the production of cervical intraepithelial neoplasia. Two hundred thirty-one cervical smear samples were tested for the presence of the organisms by PCR. In addition, human papillomavirus types in the samples were determined by PCR and classified into cancer risk types of high, moderate, and low. There was no link with cervical intraepithelial neoplasia status and detection of herpes simplex virus, cytomegalovirus, Epstein-Barr virus, human herpesviruses 6 and 8, gonorrhea, or chlamydia. However, high-grade cervical intraepithelial neoplasia was found more frequently with mixed infection by moderate-risk human papillomavirus types and human herpesvirus 7 than with these papillomavirus types alone. The presence of human herpesvirus 7 may increase the oncogenic potential of moderate-risk human papillomavirus types.

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Published date: August 2001
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 348219
URI: https://eprints.soton.ac.uk/id/eprint/348219
ISSN: 0095-1137
PURE UUID: e72bced2-488c-40ca-8264-6cd05d7773fe
ORCID for S.A. Lanham: ORCID iD orcid.org/0000-0002-4516-264X

Catalogue record

Date deposited: 05 Mar 2013 10:02
Last modified: 20 Jul 2019 01:16

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